摘要
胰腺干细胞分化为胰岛细胞的生物学调控机制,是解决如何促进胰腺干细胞分化、增殖治疗糖尿病的关键。Neurogenin3(Ngn3)作为胰腺干细胞向胰岛细胞分化调控中的一个重要的转录因子,目前研究较多。为了阐述其及其信号在胰岛细胞分化发育和胰岛再生中的作用机制,本文对Ngn3的生物学特性以及其转录因子信号在促进胰岛细胞分化中的作用机制进行综述。
The biological regulation mechanism of the differentiation of pancreatic stem cells into pancreatic islet cells is the key to solve the problem of how to promote the differentiation and proliferation of pancreatic stem cells in the treatment of diabetes.Ngn3(Neurogenin3,Νgn3)as pancreatic stem cells to islet cell differentiation regulation of an important transcription factor,the present study a great many.To illustrate its signal and its role in the development and pancreas islet cell differentiation regeneration mechanism,the biological characteristics of Ngn3 and its transcription factor signal in promoting the role of islet cell differentiation mechanism were reviewed.
作者
洪洋
杨开明
HONG Yang(Basic Medical College,Dali college,Dali,Yunnan,671000,China)
出处
《齐齐哈尔医学院学报》
2020年第14期1797-1799,共3页
Journal of Qiqihar Medical University
关键词
Ngn3
转录因子
胰岛分化
糖尿病
Ngn3
Transcription factors
Islet differentiation
Diabetes