二维斑点追踪显像评价法舒地尔对肺动脉高压患者室间隔心肌功能的影响

The Effect of Fasudil on Interventricular Septum Myocardial Function Assessed by Two-dimensional Speckle Tracking Imaging in Patients with Pulmonary Arterial Hypertension

目的:应用二维斑点追踪显像(2D-STI)评价法舒地尔对肺动脉高压(pulmonary artery hypertension,PAH)患者室间隔心肌功能的影响。方法:48例PAH患者分别于法舒地尔治疗前后行常规超声测量并记录心尖四腔观动态图像,应用2D-STI测量室间隔纵向收缩期峰值应变(S)、纵向收缩期峰值应变率(SRs)、纵向舒张早期峰值应变率(SRe)、纵向舒张早/晚期峰值应变率比值(SRe/SRa)。结果:法舒地尔治疗2周后,PAH患者室间隔S、SRs、SRe、SRe/SRa均显著增高,差异有统计学意义(P<0.05)。结论:2D-STI是评价法舒地尔对PAH患者室间隔心肌功能影响的一种新方法,对于指导临床干预和评估预后有一定的应用价值。

Objective Two-dimensional speckle tracking imaging(2D-STI)was used to evaluate the effect of fasudil on septal myocardial function in patients with pulmonary artery hypertension(PAH).Methods 48 patients with PAH under⁃went routine ultrasound measurements before and after fasudil treatment and recorded dynamic apical four-chamber views.The 2DSTI was used to measure the longitudinal systolic peak strain(S),longitudinal systolic peak strain rate(SRs),lon⁃gitudinal Early diastolic peak strain rate(SRe),and longitudinal early/late diastolic peak strain rate ratio(SRe/SRa).Results After 2 weeks of fasudil treatment,the ventricular septal S,SRs,SRe and SRe/SRa were significantly increased in patients with PAH(P<0.05).Conclusion 2D-STI is a new method for evaluating the effects of fasudil on ventricular sep⁃tal myocardial function in patients with PAH,which has certain application value for guiding clinical intervention and prog⁃nosis assessment.