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维生素B2对儿童偏头痛防治有效性的meta分析

Efficacy of vitamin B2 in prevention and treatment of migraine in children:a meta-analysis
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摘要 目的评价维生素B2对儿童偏头痛发作频率和缓解疼痛程度的有效性。方法检索PubMed、 EMbase、the Cochrane Library、CNKI、维普、万方数据库,截至2018年4月30日的所有有关维生素B2对儿童偏头痛预防和治疗作用的随机对照试验。依据纳入和排除标准筛选文献,提取资料并进行方法学质量评估。采用RevMan 5.3软件进行meta分析。结果共纳入6组随机对照试验。meta分析结果表明:治疗组偏头痛发病率低于对照组(安慰剂),差异有统计学意义(MD=-1.97,95%CI:-3.72^-0.23,P=0.03),治疗组偏头痛疼痛指数与对照组差异无统计学意义(SMD=-0.53,95%Cl:-1.37~0.30,P=0.21),剔除方法学质量评分较低的研究,敏感性分析的结果不变。亚组分析显示低剂量(50 mg)可能是影响异质升高的原因。结论现有试验证据表明,维生素B2可以降低儿童偏头痛发生频率,但对减轻偏头痛疼痛指数无明显影响。 Objective To evaluate the effectiveness of vitamin B2 on reducing the frequency of migraine attack and pain relief in children. Methods PubMed, EMbase, the Cochrane Library, CNKI, VIP and Wanfang database were searched for all randomized-controlled trials of vitamin B2 in the prevention and treatment of migraine in children as of April 30, 2018. The literatures were screened according to inclusion and exclusion criteria, the data were extracted and the methodological quality was assessed. RevMan 5.3 was used for meta analysis. Results A total of 6 groups of randomized-controlled trials were included. The results of meta analysis showed that the incidence of migraine in the treatment group was lower than that in the control group(placebo), with a statistically significant difference(MD=-1.97, 95%CI:-3.72-0.23, P=0.03). No statistically significant difference was found in migraine pain index between the treatment group and the control group(SMD=-0.53, 95%Cl:-1.37-0.30, P=0.21). The results of sensitivity analysis remained unchanged after excluding trails with lower methodological quality scores. Subgroup analysis showed that low dose(50 mg) might be the cause of heterogeneous elevation. Conclusions The existing experimental evidence shows that vitamin B2 can reduce the frequency of migraine attack in children, but has no significant effect on reducing migraine pain index.
作者 蔡响 刘桃成 吕媛 易尚辉 查文婷 CAI Xiang;LIU Tao-cheng;LYU Yuan;YI Shang-hui;ZHA Wen-ting(Medical College of Hunan Normal Universily,Changsha,Ilunan 410013,China;Hunan Provincial Key Laboratory of Molecular Epidemiology,Hunan Nornal Universiy,Changsha,Hunan 410013,China)
出处 《实用预防医学》 CAS 2020年第9期1077-1080,共4页 Practical Preventive Medicine
基金 湘教通[2017]451号 湘教通[2017]452号,JG2018B041。
关键词 维生素B2 儿童偏头痛 META分析 vitamin B2 childhood migraine meta analysis
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  • 1陶行,尹小俭.留守儿童、随迁儿童和城市儿童营养状况的比较研究[J].体育与科学,2015,36(5):112-120. 被引量:20
  • 2周福林,段成荣.留守儿童研究综述[J].人口学刊,2006,28(3):60-64. 被引量:389
  • 3张海菊,王玉玮,孙若鹏,王贵菊.偏头痛患儿的心理行为特征研究[J].中国儿童保健杂志,2007,15(4):357-359. 被引量:3
  • 4Lewis D, Ashwal S, Hershey A, et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society[J]. Neurology, 2004, 63(12): 2215- 2224.
  • 5Powers SW, Kashikar-Zuck SM, Allen JR, et al. Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents a randomized clinical trial[J]. JAMA, 2013, 310(24): 2622-2630.
  • 6Estemalik E, Tepper S. Preventive treatment in migraine and the new US guidelines[J]. Neuropsychiatr Dis Treat, 2013, 9: 709- 720.
  • 7Connelly M. Cognitive behavioral therapy for treatment of pediatric chronic migraine[J]. JAMA, 2013, 310(24): 2617- 2618.
  • 8Shapiro RE. Preventive treatment of migraine[J]. Headache, 2012, 52(Suppl 2N): 65-69.
  • 9Headache Classification Subcommittee of the InternationalHeadache Society. The international classification of headache disorders, 2nd ed[J]. Cephalalgia, 2004, 24(Suppl 1): 9-160.
  • 10Hershey AD, Powers SW, Vockell AL, et al. PedMIDAS: Development of a questionnaire to assess disability of migraines in children[J]. Neurology, 2001, 57(11): 2034-2039.

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