3D打印技术与骨组织工程研究文献计量及研究热点可视化分析

Three-dimensional printing technology and bone tissue engineering research:literature metrology and visual analysis of research hotspots

背景:随着3D打印技术和骨组织工程的不断发展,越来越多研究将3D打印技术运用到骨组织工程研究中,但主要研究现状、热点和发展趋势还不够明确。目的:通过对3D打印与骨组织工程研究的相关文献进行文献计量和研究热点可视化分析,探索该领域当前研究现状、热点及发展趋势。方法:以"3D打印与骨组织工程研究"为主题检索中国知网数据库,基于CNKI文献计量可视化分析方法对3D打印技术在骨组织工程中应用的发文数量趋势、发文机构、发文期刊等进行统计分析。利用VOSviewer软件分析文献的作者合作和关键词共现网络,并结合文献对热点研究主题进行解读。结果与结论:①检索到3D打印与骨组织工程研究的相关有效文献469篇,从2014年来3D打印与骨组织工程研究的发文开始出现稳定增长的趋势,《中国组织工程研究》杂志和吉林大学是该领域发文最多的杂志和机构,文献作者形成5大团体,但各团体间的合作很少;②关键词共现网络显示,关键词共同聚类成的4个研究主题(骨组织工程支架材料、3D打印技术及其在骨科的应用、3D打印与关节置换、其他)和排名前10的关键词(3D打印技术、计算机辅助技术、骨组织工程、组织工程、骨折、骨缺损、羟基磷灰石、三维、置换、钛合金)所揭示的内容,真实反映了当前3D打印与骨组织工程研究的现状与热点,可为该领域研究者在选择研究方向时提供参考。

BACKGROUND:With the continuous development of three-dimensional(3D)printing technology and bone tissue engineering,more and more studies have applied 3D printing technology to bone tissue engineering,but the main research status,hot spots and development trend are not clear enough.OBJECTIVE:To explore the current research status,hotspots and development trends of this field through the literature metrology and visual analysis of research hotspots of 3D printing and bone tissue engineering.METHODS:The CNKI database was searched under the theme of“3D printing and bone tissue engineering research”.Based on the quantitative visual analysismethod of CNKI literature,the author made a statistical analysis on the trend of the number of publications,publishing institutions and journals of theapplication of 3D printing technology in bone tissue engineering.VOSviewer software was used to analyze the author collaboration and keyword co-occurrencenetwork of the literature,and the hot research topic was interpreted based on the literature.RESULTS AND CONCLUSION:(1)A total of 469 effective articles related to 3D printing and bone tissue engineering were retrieved.Since 2014,the researchon 3D printing and bone tissue engineering has shown a steady growth trend.Chinese Journal of Tissue Engineering Research and Jilin University are themost published journal and institution in this field,respectively.The authors of the literature form five major groups,but there is very little cooperationbetween the groups.(2)Keywords co-occurrence network shows that the contents revealed by keywords commonly clustering into four research topics(bonetissue engineering scaffold material,3D printing technology and its application in orthopedics,3D printing and joint replacement,and others)and the top10 keywords(3D printing technology,computer aided technology,bone tissue engineering,tissue engineering,fracture,bone defect,hydroxyapatite,threedimensional,replacement,titanium alloy)really reflect the present situation and the hotspots of current 3D printing and the bone tissue engineering research,which can provide a reference for researchers in this field when choosing a research direction.