骨组织工程材料治疗骨缺损疾病在体内实验中的应用

Application of bone tissue engineering materials in the treatment of bone defect diseases in vivo

背景:应用骨组织工程材料来治疗骨缺损疾病是现在研究的热点,材料选择和体内实验设计是研究的重点。目的:总结近10年来在体内实验中骨组织工程材料修复骨缺损模型的研究进展。方法:以"骨组织工程、骨缺损和体内实验"为中文检索词,检索CNKI、万方数据库;以"Bone tissue engineering,Bone defect and In vivo experiment"为英文关键词,检索PubMed数据库,检索时间范围为2010年1月至2019年12月,共检索得到264篇文献,经筛选后对符合标准的74篇文献进行归纳分析。结果与结论:骨组织工程是治疗骨缺损疾病的新手段,但实际应用的骨组织工程材料种类繁多,单一材料不可避免出现材料应用的局限性,而复合材料能改善材料性能,提高骨修复能力。同时,体内实验是验证材料实际应用能力的有力检验,能检测出体外实验未能发现的不足之处,为骨组织工程材料的实际应用提供数据支持。

BACKGROUND:The application of bone tissue engineering materials to treat bone defect diseases is a hot topic of current research.Material selection and design of in vivo experiments are the focus of research.OBJECTIVE:To summarize the research progress of bone tissue engineering materials for repairing bone defects in vivo in the past 10 years.METHODS:A search was conducted in CNKI,Wanfang,and PubMed with the key words of“bone tissue engineering,bone defect and in vivo experiment”for articles published from January 2010 to December 2019.Totally 264 articles were retrieved,and 74 eligible articles were finally summarized after screening.RESULTS AND CONCLUSION:Bone tissue engineering is a new method for treating bone defect diseases,but there are many types of bone tissue engineering materials in practical application.The single material inevitably has limitations in the application of materials.Composite materials can improve material properties and bone repair capacity.Simultaneously,the in vivo experiment is a powerful test to verify the practical application of the material,and it can detect the shortcomings that were not found in the in vitro experiments,and provide data support for the practical application of bone tissue engineering materials.