动态检测外周血循环肿瘤细胞在晚期乳腺癌化疗中的意义

Significance of dynamic detection of peripheral blood circulatingtumor cells in chemotherapy for advanced breast cancer

目的探讨动态检测循环肿瘤细胞(CTC)在晚期乳腺癌化疗中的意义。方法选择2018年11月—2019年12月本院收治的晚期乳腺癌患者52例作为研究对象,给予标准化疗方案,21天为1个疗程,分别于化疗前、化疗后1月、化疗后2月检测患者外周血CTC计数;另选择同时以良性乳腺肿瘤患者54例为对照组。结果晚期乳腺癌组与良性组外周血液循环中CTC个数存在显著性差异(P<0.05),且化疗前后CTC个数同样存在显著性差异(P<0.05)。结论动态检测外周血CTC对于乳腺癌患者的复发转移及晚期乳腺癌化疗疗效的验证有显著的意义。

Objective To explore the significance of dynamic detection of circulating tumor cell(CTC)in chemotherapy for advanced breast cancer patients.Methods Fifty-two patients with advanced breast cancer admitted to our hospital from November 2018 to December 2019 were selected and given standard chemotherapy regimen,with 21 days as a course of treatment.The peripheral blood CTC counts of patients were detected before medication,1 month after chemotherapy and 2 months after chemotherapy respectively,while 54 patients with benign breast tumors were taken as control group.Results Statistical analysis showed that there was significant difference in the number of CTCS in blood circulation between the advanced breast cancer group and the benign group(P<0.05),and there was also significant difference in the number of CTCS before and after chemotherapy(P<0.05).Conclusions Dynamic detection of peripheral blood circulating tumor cells is of great significance for the recurrence and metastasis of breast cancer patients and the verification of curative effect after chemotherapy for advanced breast cancer.