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食管癌术后调强放疗致放射性胃炎的影响因素分析 被引量:2

Analysis of the influencing factors of radiation gastritis induced by intensity-modulated radiotherapy after esophageal cancer operation
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摘要 目的:分析食管癌术后调强放疗致急性放射性胃炎的相关因素。方法:采用剂量-体积直方图计算60例食管癌术后调强放疗病人的胸腔胃最大剂量(Dmax)、胸腔胃平均剂量(Dmean)、不同位置胸腔胃体积、胃受照体积百分比(V5、V10、V20、V30、V40、V45、V50)、胃受照体积(aV5、aV10、aV20、aV30、aV40、aV45、aV50)。分析不同位置胸腔胃体积差别。ROC曲线确定最佳临界值,logistic多因素分析确定预测指标。结果:右侧胸腔胃体积与左侧、纵隔胸腔胃体积比较差异有统计学意义(P<0.05)。V50、aV50是预测急性放射性胃炎的指标(P<0.01)。结论:食管癌术后调强放疗计划评估中需要重点关注胸腔胃V50和aV50的评估。 Objective:To analyze the related factors of acute radiation gastritis induced by intensity-modulated radiotherapy after esophageal cancer surgery.Methods:The maximum dose(Dmax),mean dose(Dmean),intrathoracic stomach volume in different locations,illuminated volume percent(V5,V10,V20,V30,V40,V45 and V50),intrathoracic stomach illuminated volume(aV5,aV10,aV20,aV30,aV40 aV45 and aV50)in 60 esophageal cancer patients treated with postoperative intensity modulated cancer radiotherapy were calculated using the dose volume histogram.The differences of intrathoracic stomach volume in different locations were analyzed.The optimal critical value was determined by ROC curve,and the predictive index was determined by logistic multivariate analysis.Results:The differences of the intrathoracic stomach volume between the right side and left side,mediastinum were statistically significant(P<0.05).The V50 and aV50 were the indicator to predict acute radioation gastritis(P<0.01).Conclusions:In the evaluation of postoperative induced by intensity-modulated radiotherapy plan for esophageal cancer,the evaluation of V50 and aV50 in pleural and gastric areas should be greatly focused on.
作者 葛宁 刘浩武 康亚辉 张洪波 GE Ning;LIU Hao-wu;KANG Ya-hui;ZHANG Hong-bo(Department of Radiotherapy,Anhui Tumor Hospital,The First Affiliated Hospital of University of Science and Technology of China(West),Hefei Anhui 230031,China)
出处 《蚌埠医学院学报》 CAS 2020年第8期1004-1007,共4页 Journal of Bengbu Medical College
基金 “科大新医学”联合基金培养项目(WK9110000132) 安徽省自然科学基金青年基金项目(1608085QH214)。
关键词 食管肿瘤 术后放疗 放射性胃炎 esophageal neoplasms postoperative radiotherapy radiation gastritis
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