期刊文献+

瑞舒伐他汀在高龄冠心病患者经皮冠状动脉介入术后的应用 被引量:1

下载PDF
导出
摘要 目的研究瑞舒伐他汀在高龄冠心病(CHD)患者经皮冠脉介入术(PCI)后的应用。方法选取2018年1月至2019年7月就诊于郸城县人民医院的96例高龄CHD患者,均接受PCI治疗,依据术后治疗方式分为对照组和观察组,各48例。对照组接受氯吡格雷、阿司匹林治疗,观察组在对照组基础上接受瑞舒伐他汀治疗。对比两组治疗前后心肌酶谱[肌酸激酶(CK)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)]水平、血清氨基末端脑钠尿肽前体(NT-proBNP)水平,随访3个月,记录两组主要不良心血管事件(MACE)发生率及预后[西雅图心绞痛量表(SAQ)评分]。结果治疗后,两组CK、LDH、CK-MB水平均较治疗前降低,且观察组CK、LDH、CK-MB水平均低于对照组(均P<0.05)。治疗后,两组血清NT-proBNP水平均低于治疗前,且观察组低于对照组(均P<0.001)。随访3个月,观察组MACE发生率[6.25%(3/48)]较对照组[22.92%(11/48)]低(均P<0.05)。治疗后,两组SAQ评分均较治疗前升高,且观察组高于对照组(均P<0.001)。结论将瑞舒伐他汀用于CHD患者PCI术后,可降低MACE发生风险,调节心肌酶谱水平,改善血清NT-proBNP水平,提高预后。
作者 郭环宇
出处 《河南医学研究》 CAS 2020年第24期4531-4533,共3页 Henan Medical Research
  • 相关文献

参考文献7

二级参考文献67

  • 1丁嵩,何奔,孙瑜,刘建平,杜勇平,沈节艳,金叔宣,沈珑.稳定型心绞痛及急性冠脉综合征患者脑钠肽浓度的变化和意义[J].中国心血管病研究,2005,3(12):890-892. 被引量:20
  • 2刘金波,夏岳,戚国庆,苗成龙,张晓霞,刘坤申.老年冠心病患者血浆同型半胱氨酸水平与内皮依赖性血管舒张功能关系探讨[J].河北医药,2007,29(2):111-113. 被引量:11
  • 3田玮,付研,王勇.脑利钠肽与急性心肌梗死患者预后的临床探讨[J].北京医学,2007,29(6):352-355. 被引量:9
  • 4Liu HL, Yang Y, Yang SL, et al. Administration of a loading dose of atorvastatin before percutaneous coronary intervention pre- vents inflammation and reduces myocardial injury in STEMI pa- tients: a randomized clinical study. Clin Ther. 2013, 35 : 261- 272.
  • 5Pasceri V, Patti G, Nusca A, et al. Randomized trial of atorvas- tatin for reduction of myocardial damage during coronary interven- tion: results from the ARMYDA (Atorvastatin for Reduction of MYocardial Damage during Angioplasty ) study. Circulation, 2004, 110:6744578.
  • 6Patti G, Pasceri V, Colonra G, eta. Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes un- dergoing early percutaneous coronary" intervention: results of the ARMYDA-ACS randomized trial. J Am Coil Cardiol, 2007, 49 : 1272-1278.
  • 7Novel approaches for preventing or limiting events (Naples) II trial: impact of a single high loading dose of atorvastatin on periprocedural myocardial infarction. J Am Coil Cardiol, 2009, 54:2157-2163.
  • 8Cholesterol Treatment Trialists' (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol : a meta- analysis of data from 170000 participants in 26 randomised trials. Lancet, 2010, 376:1670-1681.
  • 9Harley CR, Gandhi S, Blasetto J, et al. Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other st- atins in routine clinical practice. Am J Geriatr Pharmacother, 2007, 5 : 185-194.
  • 10Chalasani N, Aljadhey H, Kesterson J, et al. Patients with ele-vated liver enzymes are higher risk for statin hepatotoxicity. Gas- troenterology, 2004, 126: 1287-1292.

共引文献105

同被引文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部