7例新型冠状病毒肺炎患者的临床特点及影响预后的相关性分析

Correlation analysis of clinical characteristics and prognosis of 7 patients with COVID-19

目的:分析本院收治的7例新型冠状病毒肺炎(COVID-19)的临床特点及影响预后的相关因素。方法:回顾性分析本院2020年1月21日至2020年2月7日收治新型冠状病毒肺炎的流行病学特点、临床表现、实验室检查、影像学特征及转归。结果:7例COVID-19中,男性4例,女性3例;年龄38~78岁;4例存在基础疾病,6例BMI过重。以首发症状为发热、咳嗽4例,2例仅有发热,1例无症状;普通型病例1例,重型5例,危重型1例。血常规白细胞总数正常或轻度升高,淋巴细胞绝对值均降低;肺部CT检查均有病毒性肺炎的影像学改变,2例有胸腔积液,1例胸膜增厚。采用抗病毒治疗为主的综合治疗后,6例COVID-19康复出院,1例病情好转并在康复治疗中。结论:核酸检测是新冠病毒感染唯一确诊证据,高分辨率CT检查是COVID-19较好的手段之一,淋巴细胞水平可能与COVID-19严重程度密切相关,抗新型冠状病毒药物的疗效有待进一步研究。

Objective:To investigate the clinical characteristics and therapeutic procedure for 7 patients with Corona Virus Disease 2019(COVID-19)admitted to our hospital.Methods:7 patients infected with COVID-19 referred to our hospital between January 21,2020 and February 7,2020 were retrospectively analyzed.The data reviewed included those of clinical manifestations,laboratory investigation and Radiographic features.Results:Among the 7 patients,there were 4 males and 3 females,aged from 38 to 78 years old.4 of them had chronic medical illness,6 of them had overweight BMI.The first symptoms were fever and cough in 4 cases,only fever in 2 cases and no symptom in 1 case.As for the clinical classification one of the 7 patients was ordinary,5 of them were severe,1of them was critically severe.Their routine blood test revealed normal or slightly higher while the lymphocyte count in peripheral blood were significantly decreased.All of the 7 patients had the imaging changes of viral pneumonia.2 of them had pleural effusion.1of them had pleural incrassation.After a variety of antiviral treatment,6 of them recovered and left the hospital,1 case got better and was in rehabilitation treatment.Conclusion:Nucleic acid detection the only evidence of COVID-19,high-resolution CT is a good tool for screening.Lymphocyte level may be novel coronavirus related to the severity of COVID-19.The effect of antiviral therapy needs further study.