决银颗粒治疗寻常型银屑病血热证的临床研究

Clinical Study on Jueyin Granule Treating Psoriasis Vulgaris with Blood Heat Symptom

目的探讨决银颗粒治疗寻常型银屑病血热证患者的临床疗效及对外周血干扰素-γ(IFN-γ)、白细胞介素-23(IL-23)含量的影响。方法76例寻常型银屑病血热证患者随机分为对照组与观察组各38例,对照组与观察组分别内服复方青黛胶囊及决银颗粒,2组同时均外用卡泊三醇,观察2组患者皮损面积及严重程度指数(PASI评分)、外周血IFN-γ、IL-23水平以及2组治愈病例复发情况。结果治疗后2组PASI评分均降低(P<0.01),观察组低于对照组(P<0.01);观察组有效率优于对照组(P<0.05);2组治疗后IFN-γ、IL-23水平均低于治疗前(P<0.01),但观察组较对照组下降更明显(P<0.05~0.01);治疗结束后随访6个月,观察组复发率低于对照组(P<0.01)。结论决银颗粒能有效降低寻常型银屑病血热证患者PASI积分及血清IFN-γ、IL-23含量且能降低复发率,有较好的临床疗效。

OBSJECTIVE To discuss the clinical study on Jueyin Granule in the treatment of psoriasis vulgaris with blood heat symptom and its significance on changing peripheral blood interferon-γ(IFN-γ)level and leukocyte interleukin-23(IL-23)level.METHODS 76 patients with blood heat symptom admitted in the Affiliated Hospital of Gansu University of Chinese Medicine were randomly divided into the control group and the observation group with 38 cases each.The control group was given Qingdai Compound Capsule while the observation group Jueyin Granule.Besides,calcipotriol was given to both groups.The observed indicators included the psoriasis area and severity index score(PASI score),IFN-γlevel,IL-23 level and the recurrence rate of two groups.RESULTS After treatment,PASI score decreased in both groups(P<0.01)and that in the observation group were lower(P<0.01).The effective rate in the observation group was higher than that in the control group(P<0.05).The levels of IFN-γand IL-23 in the two groups were both lower than that before treatment(P<0.01)and those in the observation group decreased more(P<0.05,P<0.01).All the patients were followed up for 6 months and it showed that the recurrence rate in the observation group was lower(P<0.01).CONCLUSION Jueyin Granule has significant efficacy in decreasing psoriasis vulgaris patients'PASI score,IFN-γlevel,IL-23 level and the recurrence rate.