3种方法筛查M蛋白的结果分析

The results of screening M protein by three methods were analyzed

目的了解广东地区多发性骨髓瘤(MM)的发病情况。方法收集来自广州金域医学检验中心广东地区2016年1月至2019年12月筛查MM的标本共10287份,采用血清蛋白电泳、血清免疫固定电泳及血清游离轻链联合检测,并对结果进行分析。结果10287份标本中共检出1996份M蛋白标本,检出阳性率为19.4%,其中651份为IgG-κ型(61.6%);405份为IgG-λ型(38.4%);227份为IgA-κ型(45.4%);273份为IgA-λ型(54.6%);74份为IgM-κ型(77.1%);22份为IgM-λ型(22.9%);4份为IgD-κ型(4.0%);97份为IgD-λ型(96.0%);1份为IgE-κ型;60份为轻链-κ型(24.8%);182份为轻链-λ型(75.2%)。结论通过联合检测,提高MM检出率,降低MM的漏诊、误诊率,及早发现、及早预防,对MM的预后治疗具有重要意义。

Objective To investigate the screening status of multiple myeloma(MM)in Guangdong.Methods A total of 10287 samples with MM from Guangzhou Kingmed Center for Clinical Laboratory from January 2016 to December 2019 in Guangdong were analyzed by serum protein electrophoresis,immuno fixation electrophoresis,serum free light chain,and the results were analyzed.Results A total of 1996 samples with M protein were detected from 10287 samples,with a detection rate of 19.4%.651 cases was IgG-κ(61.6%),405 cases was IgG-λ(38.4%);227 cases was IgA-κ(45.4%),273 cases was IgA-λ(54.6%);74 cases was IgM-κ(77.1%),22 cases was IgM-λ(22.9%);4 cases was IgD-κ(4.0%),97 cases was IgD-λ(96.0%);60 cases was light chain-κ(24.8%),182 cases was light chain-λ(75.2%).Conclusion To improve the detection rate of MM,reduce the rate of missed diagnosis and misdiagnosis of MM,have early detection and early prevention of MM by combined detection has great significance for the prognosis and treatment of MM.