慢性阻塞性肺疾病患者巨噬细胞刺激蛋白与炎症因子水平及肺功能的关系研究

Study on the relationship between macrophage stimulating protein and inflammatory factors and lung function in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)患者巨噬细胞刺激蛋白(MSP)与炎症因子水平及与肺功能的关系。方法选择2016年3月至2019年2月江西省于都县中医院收治的100例COPD患者,其中急性加重期COPD患者(AECOPD)55例作为A组,缓解期COPD患者45例作为B组,另外选择同期于本院体检中心进行体检的健康志愿者50例作为对照组。比较3组受试者血浆中MSP水平、肺功能相关指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC和FEV1占预计值百分比(FEV1%)]、血浆炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8及C-反应蛋白(CRP)]水平,并且分析MSP水平与肺功能相关指标、血浆炎症因子水平的相关性。结果A组、B组血浆MSP、TNF-α、IL-6、IL-8、CRP水平明显高于对照组,差异均有统计学意义(P<0.05),而FEV1、FVC、FEV1/FVC及FEV1%水平明显低于对照组,差异均有统计学意义(P<0.05)。A组患者血浆中MSP、TNF-α、IL-6、IL-8、CRP水平明显高于B组,而FEV1、FVC、FEV1/FVC及FEV1%水平明显低于B组,差异均有统计学意义(P<0.05)。A、B两组患者血浆中MSP水平均与TNF-α、IL-6、IL-8及CRP水平呈正相关(r=0.392~0.736,P<0.05),而与FEV1、FVC、FEV1/FVC及FEV1%呈负相关(r=-0.621^-0.349,P<0.05)。结论COPD患者血浆中MSP水平及炎症因子水平异常升高,并且MSP水平与炎症因子、肺功能密切相关,可以作为临床上辅助评估COPD的生物学指标。

Objective To explore the relationship between macrophage stimulating protein(MSP)and inflammatory factors and lung function in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 100 cases of COPD treated in the hospital from March 2016 to February 2019 were enrolled in the study,including 55 cases of acute exacerbation of COPD(A group)and 45 cases of remission COPD(B group).In addition,50 cases of healthy volunteers in physical examination center of the hospital in the same period were selected as control group.The levels of MSP in the plasma,lung function related indicators,including forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),FEV1/FVC,FEV1 percentage of expected value(FEV1%),plasma inflammatory factors level,including tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8 and C-reactive protein(CRP)in the two groups were compared.Meanwhile,the correlation between MSP level and lung function related indexes,plasma inflammatory factors were analyzed.Results The plasma levels of MSP,TNF-α,IL-6,IL-8 and CRP in group A and group B were significantly higher than those in the control group(P<0.05),and the levels of FEV1,FVC,FEV1/FVC and FEV1%in group A and group B were significantly lower than those in the control group(P<0.05).The plasma levels of MSP,TNF-α,IL-6,IL-8 and CRP in group A were significantly higher than those in group B,while the levels of FEV1,FVC,FEV1/FVC and FEV1%in group A were significantly lower than those of group B,and the differences were statistically significant(P<0.05).In both groups,the plasma levels of MSP were positively correlated with TNF-α,IL-6,IL-8 and CRP in plasma(r=0.392-0.736,P<0.05),but negatively correlated with FEV1,FVC,FEV1/FVC and FEV1%(r=-0.621--0.349,P<0.05).Conclusion The levels of MSP and inflammatory factors in plasma of COPD patients abnormally elevate,and MSP level is closely related with inflammatory factors and pulmonary function,which can be used as a clinical biological indicator in the auxiliary evaluation of COPD.