化痰散结法治疗亚急性甲状腺炎疗效及对患者炎症因子的影响

Therapeutic effect of Huatan Sanjie method on subacute thyroiditis and its effect on inflammatory factors

目的:探讨化痰散结法治疗亚急性甲状腺炎的近期疗效及对患者血清炎症因子的影响。方法:选取亚急性甲状腺炎患者80例。随机分为对照组和观察组各40例。对照组给予醋酸泼尼松治疗,观察组在对照组用药基础上给予化痰散结法治疗。比较两组治疗前后甲状腺功能指标(FT3、FT4、TSH)、血清炎症因子(TNF-α、IL-2、IL-3)变化、临床疗效及生活质量情况。结果:治疗后2、4、8周,两组患者中医症状积分均明显下降,且观察组比对照组下降更明显(P<0.05)。治疗前,两组血清FT3、FT4、TSH、TNF-α、IL-2、IL-3比较差异无统计学意义(P>0.05);两组治疗后FT3、FT4、TNF-α均降低,TSH、IL-2、IL-3均升高(P<0.05);观察组治疗后FT3、FT4、TNF-α均低于对照组,TSH、IL-2、IL-3均高于对照组(P<0.05);两组治疗期间均未出现明显不良反应,观察组总有效率95.00%高于对照组77.50%(P<0.05)。观察组治疗后生活质量明显优于对照组(P<0.05)。结论:化痰散结法可显著改善亚急性甲状腺炎患者甲状腺功能,降低血清TNF-α水平,提高IL-2、IL-3水平,临床疗效满意。

Objective:To investigate the short-term effect of Huatan Sanjie method in the treatment of subacute thyroiditis and its effect on serum inflammatory factors.Methods:80 patients with subacute thyroiditis were selected.Randomly divided into control group and observation group,40 cases each.The control group was treated with prednisone acetate,and the observation group was treated with Huatan Sanjie method on the basis of the control group.Results:After 2,4 and 8 weeks of treatment,the TCM symptom scores of the two groups decreased significantly,and the observation group decreased more significantly than the control group(P<0.05).After treatment,FT3,FT4 and TNF-αdecreased,TSH,IL-2 and IL-3 increased in the two groups(P<0.05);after treatment,FT3,FT4 and TNF-αin the observation group were lower than those in the control group,TSH,IL-2 and IL-3 were higher than those in the control group(P<0.05);during the treatment,there were no significant adverse reactions in the two groups.The total effective rate of the observation group was 95.00%higher than that of the control group(P<0.05).The quality of life in the observation group was significantly better than that in the control group(P<0.05).Conclusion:Huatan Sanjie method can significantly improve the thyroid function of patients with subacute thyroiditis,reduce the level of serum TNF-α,and improve the level of IL-2 and IL-3.The clinical effect is satisfactory,which is worthy of application and promotion.