长链非编码RNA HOXA11-AS在肝癌组织中的表达及临床意义

Expression and Clinical Significance of lnc RNA HOXA11-AS in Hepatocellular Carcinoma

目的探讨长链非编码RNA HOXA11-AS在肝癌组织中的表达及临床意义。方法纳入106例原发性肝癌患者,qRT-PCR检测肝癌及癌旁正常组织样本中长链非编码RNA HOXA11-AS的表达量,并分析其与患者临床病理特征及预后的相关性。结果长链非编码RNA HOXA11-AS在肝癌组织中的表达明显高于癌旁正常组织(2.97±0.81 vs.0.83±0.22,P<0.05);其在不同AJCC分期及是否发生淋巴结转移的肝癌组织中的表达量间的差异均有统计学意义(均P<0.05);长链非编码RNA HOXA11-AS高表达组3年生存率明显低于低表达组(22.22% vs.53.33%,P<0.05);长链非编码RNA HOXA11-AS高表达、AJCC分期增高是影响原发性肝癌患者预后的独立危险因素(均P<0.05)。结论肝癌组织中长链非编码RNA HOXA11-AS表达上调,其可能参与肝癌的发生发展,可成为肝癌患者预后评估的新指标。

Objective To investigate the expression and clinical significance of long-chain non-coding RNA(lncRNA) HOXA11-AS in hepatocellular carcinoma.Methods We included 106 patients with primary liver cancer.qRT-PCR was used to detect the expression of lncRNA HOXA11-AS in liver cancer tissues and adjacent normal tissues,and we analyzed its correlation with clinicopathological features and prognosis of the patients.Results The expression of lncRNA HOXA11-AS in liver cancer tissues was significantly higher than that in adjacent normal tissues (2.97±0.81 vs.0.83±0.22,P<0.05);it was significantly different in the liver cancer tissues with different AJCC staging and lymph node metastasis (P<0.05).The 3-year survival rate of the high lncRNA HOXA11-AS expression group was significantly lower than that of the low expression group (22.22% vs.53.33%,P<0.05).High lncRNA HOXA11-AS expression and AJCC staging were independent risk factors for the prognosis of primary liver cancer patients (P<0.05).Conclusion The expression of lncRNA HOXA11-AS in liver cancer tissues is upregulated.It may be involved in the occurrence and development of liver cancer and may become a new indicator for the prognosis evaluation of liver cancer patients.