阿维A联合窄谱中波紫外线对寻常型银屑病患者皮损程度的影响

The effect of acitretin combined with Narrow band UVB on the degree of skin lesion in patients with psoriasis vulgaris

目的探讨阿维A联合窄谱中波紫外线(NB-UVB)对寻常型银屑病患者皮损程度的影响。方法寻常型银屑病患者75例分为对照组、NB-UVB组和联合组各25例,对照组给予20 mg/d阿维A治疗,NB-UVB组给予5 J/cm 2 NB-UVB治疗,联合组予20 mg/d阿维A和5 J/cm 2 NB-UVB治疗。观察2组治疗前、治疗6周、治疗12周的皮损面积和严重性指数(PASI),统计治疗有效率及不良反应。结果治疗6、12周后,联合组的PASI低于对照组、NB-UVB组,差异有统计学意义(P<0.05)。联合组治疗有效率高于对照组、NB-UVB组,差异有统计学意义(P<0.05)。对照组、NB-UVB组、联合组的不良反应发生率差异无统计学意义(P>0.05)。结论阿维A联合NB-UVB能够有效改善寻常型银屑病患者皮损程度,疗效优于单用阿维A、NB-UVB治疗,且安全性高。

Objective To discuss the effect of Avermectin A combined with Narrow-band UVB(NB-UVB)on the degree of skin lesion in patients with psoriasis vulgaris.Methods Seventy-five patients with psoriasis vulgaris were selected from September 2017 to February 2019 in our hospital,according to the random distribution,all patients were divided into control group,NB-UVB group and combination group,25 cases in each group.The control group was treated with 20 mg/d abamectin A,the NB-UVB group was treated with 5J/cm 2 NB-UVB,and the combined group was treated with 20 mg/d abamectin A and 5J/cm 2 NB-UVB.The lesion area and severity index(PASI)were observed before treatment,6 and 12 weeks after treatment,and the effective rate and adverse reactions were observed.Results The PASI of skin lesions in the combined group after 6 and 12 weeks of treatment were significantly lower than those in the control group and NB-UVB group,the difference was statistically significant(P<0.05).The effective rate of the combined group was significantly higher than that of the control group and NB-UVB group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in control group and NB-UVB group were higher than that in combination group,but there was no significant difference(P>0.05).Conclusions Acitretin combined with NB-UVB can effectively improve the skin lesion of psoriasis vulgaris patients.Its efficacy is remarkable,and safety is high.It is worthy of clinical promotion.