吡咯啉-5-羧酸还原酶-1在恶性肿瘤中的研究进展

Research progress of pyrroline-5-carboxylic acid reductase-1 in malignant tumor

吡咯啉-5-羧酸还原酶-1(Pyrroline-5-Carboxylate Reductase-1,PYCR1)是一种线粒体酶,其基因突变可导致人类皮肤松弛症。近年研究证明PYCR1能通过影响脯氨酸代谢发挥促进肿瘤生长增殖的作用。PYCR1在多种恶性肿瘤中高表达,且其表达水平与患者预后负相关。因此,PYCR1可能可以作为一种新型标志物,应用于肿瘤的诊断和预后,并有望成为肿瘤治疗的新靶点。

Pyrroline-5-carboxylate Reductase-1(PYCR1)is a kind of mitochondrial enzyme,and its gene mutation could lead to human skin relaxation.Recent studies have shown that PYCR1 could promote tumor growth and proliferation by affecting praline metabolism.PYCR1 was highly expressed in several kinds of cancers,and the level of expression of PYCR1 was negatively related to the prognosis of patients.Therefore,PYCR1 may be used as a new marker in the diagnosis and prognosis of tumor,and may become a new target of tumor treatment.