儿童中性粒细胞缺乏症伴发热的抗感染治疗方案选择及合理用药

Anti-infective Treatment Options and Rational Drug Use in Children with Febrile Neutropenia

儿童中性粒细胞缺乏症伴发热期间易合并重症感染,治疗延误可能增加死亡概率,因此,在没有明确病原菌时,及时的广谱抗菌治疗至关重要。本文通过复习国内外指南及相关文献,从合理使用抗菌药物角度对儿童中性粒细胞缺乏症伴发热的管理以及经验抗感染治疗进行系统阐述,以期为临床合理使用抗菌药物,减少耐药菌的出现,减少药物的成本和副作用提供参考。

Children with febrile neutropenia(FN)are prone to severe infections,and the treatment delay may increase mortality.Therefore,timely initiation of empirical broad-spectrum antibiotics therapy is of utmost importance with FN,even if there is no evidence for a documented infection.Through reviewing the domestic and foreign guidelines and related literature,the management of FN in children and the experience of anti-infective treatment were systematically described from the perspective of rational use of antibiotics,so as to provide reference for the rational use of antibiotics in clinical practice,to minimize the emergence of multi-drug resistant(MDR)bacteria and to reduce the costs and adverse drug reactions of these drugs.