免疫球蛋白在NICU败血症早产儿中的应用及对血清IgG水平的影响

Application of Immunoglobulin in Sepsis Premature Infants in NICU and its Influences on Serum IgG Level

目的探讨免疫球蛋白(IVIG)在新生儿重症监护病房(NICU)败血症早产儿中的应用及对血清免疫球蛋白G(IgG)水平的影响。方法选取2013年1月至2019年1月医院新生儿科收治的30例在NICU中的败血症早产儿,并根据随机数字表法将其分为对照组(常规治疗)和观察组(在常规治疗的基础上给予IVIG治疗)各15例;统计2组的临床疗效;比较2组体温稳定时间、临床恢复时间和住院时间;比较2组治疗前、后的血清C反应蛋白(CRP)、降钙素原(PCT)和IgG水平。结果观察组、对照组的治疗有效率分别为86.67%、73.33%,比较差异无统计学意义(P>0.05);观察组的体温稳定时间、临床恢复时间及住院时间均短于对照组(P<0.05);观察组经过治疗后,血清CRP、PCT水平低于对照组(P<0.05),IgG水平高于对照组(P<0.05)。结论IVIG能够缩短在NICU中败血症早产儿的病情转归时间,抑制炎性因子表达水平,提高免疫力。

Objective To investigate the application of immunoglobulin(IVIG)in sepsis premature infants in neonatal intensive care unit(NICU)and its influences on serum immunoglobulin G(IgG)level.Methods 30 sepsis premature infants in NICU who were admitted to neonatology department of the hospital from January 2013 to January 2019 were enrolled.They were divided into control group(routine treatment)and observation group(IVIG on basis of routine treatment)according to random number table method,15 cases in each group.The clinical curative effect of the two groups was statistically analyzed.The temperature stability time,clinical recovery time and hospitalization time were compared between the two groups.The levels of serum C-reactive protein(CRP),procalcitonin(PCT)and IgG before and after treatment were compared between the two groups.Results The response rates of treatment in observation group and control group were 86.67%and 73.33%,respectively(P>0.05).The temperature stability time,clinical recovery time and hospitalization time of observation group were shorter than those of control group(P<0.05).After treatment,levels of serum CRP and PCT in observation group were lower than those in control group(P<0.05),while IgG level was higher than that in control group(P<0.05).Conclusion IVIG can shorten disease outcome time of sepsis premature infants in NICU,inhibit expression levels of inflammatory factors,and improve immunity.