血清Pro GRP、CYFRA21-1检测联合HRCT扫描对肺癌的诊断价值研究

Diagnostic Value of Serum ProGRP,CYFRA21-1 Test Combined with HRCT Scan for Lung Cancer

目的探究血清ProGRP、CYFRA21-1检测联合高分辨率CT(HRCT)扫描对肺癌的诊断价值。方法回顾性分析本院2017年2月至2019年6月收治的80例肺癌患者的临床资料,对比血清ProGRP、CYFRA21-1、HRCT检查以及三种联合检查对肺癌的诊断准确性、敏感性、特异性差异。结果血清ProGRP对肺癌的诊断灵敏性、特异性和准确性分别为71.25%、68.75%、70.00%,CYFRA21-1对肺癌的诊断灵敏性、特异性和准确性分别为72.50%、71.25%、73.75%,HRCT检查对肺癌的诊断灵敏性、特异性和准确性分别为77.50%、73.75%、76.25%(P>0.05);血清ProGRP、CYFRA21-1、HRCT检查三种联合检查对肺癌的诊断灵敏性、特异性和准确性分别为96.25%、88.57%、95.00%,明显高于单一的血清ProGRP、CYFRA21-1及HRCT检查(P<0.05)。结论血清ProGRP、CYFRA21-1、HRCT三者联合有助于提高肺癌的诊断准确性、敏感性、特异性。

Objective To explore the diagnostic value of serum ProGRP,CYFRA21-1 testcombined with HRCT scan for lung cancer.Method The clinical data of 80 patients with lung cancer admitted to our hospital from February 2017 to June 2019 were analyzed retrospectively.The imaging features of HRCT and the results of serum ProGRP and CYFRA21-1 examinations were observed and analyzed.The accuracy,sensitivity and specificity of serum ProGRP,CYFRA21-1,HRCT and combination of them were compared.Results The diagnostic sensitivity,specificity and accuracy of serum ProGRP for lung cancer were 71.25%,68.75%,and 70.00%,respectively.The sensitivity,specificity,and accuracy of CYFRA21-1 for lung cancer were 72.50%,71.25%,and 73.75%,respectively.The sensitivity,specificity and accuracy of HRCT examination for lung cancer were 77.50%,73.75%,and 76.25%,respectively(P>0.05).The sensitivity,specificity,and accuracy of combination for the diagnosis of lung cancer were 96.25%,88.57%,and 95.00%,respectively,which were significantly higher than those of single serum ProGRP,CYFRA21-1,and HRCT(P<0.05).Conclusion The combination of serum ProGRP,CYFRA21-1 and HRCT can significantly improve the diagnostic accuracy,sensitivity and specificity for lung cancer.