儿童紫癜性肾炎治疗进展

Progress in the treatment of henoch schonlein purpura nephritis in children

过敏性紫癜又称IgA血管炎,非血小板减少性紫癜是其主要临床表现,与此同时,还会出现关节炎、关节痛等症状。患者的其他器官也会受累,如消化道、肾脏等,疾病发展多呈良性自限性过程。紫癜性肾炎是过敏性紫癜常见的并发症,多在过敏性紫癜起病6个月内发病,发病机制尚不完全明确。过敏性紫癜的近期预后主要受消化道出血影响,而远期预后则取决于肾脏有无受累及受累严重程度,据报道20%~80%的患儿出现肾损害,可表现为持续性血尿、蛋白尿、肾病综合征,甚至1%~17%出现肾功能衰竭。

Henoch schonlein purpura is also called IgA vasculitis.Non thrombocytopenic pura is its main clinical manifestation.At the same time,there will be arthritis,arthralgia and other symptoms.Other organs of the patient will also be affected,such as digestive tract,kidney and so on.The development of the disease is mostly a benign self limiting process.Henoch schonlein purpura nephritis is a common complication of allergic purpura,it usually occurs within 6 months after the onset of Henoch schonlein purpura,the pathogenesis is not completely clear.The short-term prognosis of Henoch schonlein purpura is mainly affected by gastrointestinal hemorrhage,while the long-term prognosis depends on whether the kidney is involved and the severity of the involvement.It is reported that about 20%~80%of the children have renal damage,which can be manifested as persistent hematuria,albuminuria,nephrotic syndrome,or even 1%~17%of them have renal failure.