不同剂量阿托伐他汀治疗冠心病患者的临床疗效分析

Analysis of clinical effect of different doses of atorvastatin in the treatment of patients with coronary heart disease

目的:探讨不同剂量阿托伐他汀治疗冠心病患者的临床疗效。方法:2018年1月-2019年12月收治冠心病患者100例,随机分为两组,各50例。对照组采用阿托伐他汀10 mg治疗;试验组采用阿托伐他汀20 mg治疗。比较两组临床治疗效果。结果:试验组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。试验组治疗后左心室射血分数(LVEF)、脑钠肽(BNP)水平明显高于对照组,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)水平明显低于对照组,差异有统计学意义(P<0.05)。试验组治疗后白介素6(IL-6)、肿瘤坏死因子(TNF-α)、超敏C反应蛋白(hs-CRP)水平均明显低于对照组,差异有统计学意义(P<0.05)。结论:冠心病患者接受阿托伐他汀20 mg治疗,整体治疗效果较理想,且治疗后心功能明显改善,生理指标改善显著。

Objective:To explore the clinical effect of different doses of atorvastatin in the treatment of patients with coronary heart disease.Methods:From January 2018 to December 2019,100 patients with coronary heart disease were selected,they were randomly divided into the two groups with 50 cases in each group.The control group was treated with 10 mg atorvastatin.The experimental group was treated with 20 mg atorvastatin.We compared the clinical therapeutic effect between the two groups.Results:The total effective rate of the experimental group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The level of BNP and LVEF in the experimental group after treatmnet was significantly higher than that in the control group,while the level of LVESD and LVEDd was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The levels of IL-6,hs-CRP and TNF-αin the experimental group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion:Patients with coronary heart disease received 20 mg of atorvastatin,the overall treatment effect is ideal,and the patients'heart function and physiological index improved significantly after treatment,so the application value is high.