盐酸西替利嗪与依巴斯汀治疗慢性荨麻疹临床对比研究

Clinical comparative research of cetirizine hydrochloride and ebastine in the treatment of chronic urticaria

目的:分析盐酸西替利嗪与依巴斯汀治疗慢性荨麻疹的临床效果。方法:2017年12月-2019年12月收治慢性荨麻疹患者90例,随机分为两组,各45例。对照组给予盐酸西替利嗪治疗,观察组在盐酸西替利嗪基础上加用依巴斯汀治疗,比较两组治疗效果。结果:观察组临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组治疗后血清IgE及嗜酸性粒细胞水平均低于对照组,差异有统计学意义(P<0.05)。结论:盐酸西替利嗪联合依巴斯汀治疗慢性荨麻疹,临床疗效显著,可改善血清IgE及嗜酸性粒细胞水平。

Objective:To analyze the clinical effect of cetirizine hydrochloride and ebastine for chronic urticaria.Methods:From December 2017 to December 2019,90 patients with chronic urticaria were enrolled,they were randomly divided into two groups with 45 cases in each group.The control group was treated with cetirizine hydrochloride,and the observation group was treated with ebastine on the basis of cetirizine hydrochloride.The therapeutic effects between the two groups was compared.Results:The total clinical effective rate of observation group was significantly higher than the control group,the difference was statistically significant(P<0.05).After treatment,the IgE and eosinophil levels in serum of the observation group were all lower than the control group,the differences were statistically significant(P<0.05).Conclusion:Cetirizine hydrochloride combined with ebastine in the treatment of chronic urticaria,the clinical effect is significant,it can improve serum IgE and eosinophil levels.