联合筛查和单一细胞学筛查宫颈癌的比较分析

Comparative analysis of packaging screening and single cytological screening for cervical cancer

目的:比较宫颈癌的两种筛查方式,提高宫颈癌筛查的阳性率,降低漏诊率。方法:选取2016-2018年参加宫颈癌筛查的女性患者4744例,其中2359例采用液基薄层细胞学筛查(TCT),2385例行联合筛查[TCT+人乳头瘤病毒(HPV)病毒检测]。比较两组筛查结果。结果:联合筛查组检出HPV阳性273例,检出率为11.45%。两组细胞学筛查宫颈异常病例比较,差异无统计学意义(P>0.05)。根据阴道镜第三阶梯的诊断,联合筛查组HSIL病变检出率明显高于单一细胞学筛查组,差异有统计学意义(P<0.05)。结论:联合筛查对HSIL宫颈病变的检出率明显高于单一细胞学筛查,虽然成本较高,但筛查间隔的时间较长,且可以指导HPV疫苗的接种。

Objective:To compare the two screening methods of cervical cancer,improve the positive rate of cervical cancer screening and reduce the rate of missed diagnosis.Methods:From 2016 to 2018,4744 cases of patients who received cervical cancer screening were enrolled,among them,2359 cases were screened by liquid-based thin-layer cytology test(TCT),2385 cases were screened by packaging screening(TCT and HPV virus detection).The screening results between the two groups was compared.Results:273 cases tested positive for HPV by packaging screening,the detection rate was 11.45%.The cases of cervical abnormal of the two groups was compared,the difference was not statistically significant(P>0.05).According to the diagnosis of the third step of colposcopy,the detection rate of HSIL lesions in packaging screening group was significantly higher than that in single cytological screening group,the difference was statistically significant(P<0.05).Conclusion:The detection rate of packaging screening for HSIL cervical lesions is significantly higher than that of single cytological screening,although the cost is high,but the time interval of screening is longer and it can guide the HPV vaccination.