脑电图相位振幅耦合在癫痫研究中的应用

Application of phase-amplitude coupling of electroencephalogram in epilepsy research

EEG不同频段的神经振荡并不是独立的,它们之间可以相互影响和调节。不同频段之间的耦合现象叫做交叉频率耦合(CFC),其中包括相位同步、振幅共调节和相位振幅耦合(PAC)。PAC是指高频活动(gamma、ripples、fast ripples)的振幅随着低频活动(delta、theta、alpha、beta)的相位变化发生一定调节。以往研究认为PAC与记忆、认知有关。近几年的研究发现,发作间期和发作期PAC强度的变化可以定位癫痫起始区或致痫区、预测癫痫的发生及手术预后。本文将从PAC的产生机制、PAC的计算方法、生理性PAC、病理性PAC与致痫区的关系几个方面做一文献综述,以总结EEG PAC在癫痫研究中的应用。

Different frequency oscillations of EEG are not isolated, they can interact and modulate with each other. The coupling of different frequencies is named as cross-frequency coupling(CFC), including phase synchronization, amplitude co-modulation and phase-amplitude coupling(PAC). PAC indicates that the amplitude of high-frequency activities(gamma, ripples, fast ripples) is modulated by the phase of low-frequency activities(delta, theta, alpha, beta). Previous researches claimed that PAC is correlated with memory consolidation and cognition. In decade, some researches demonstrated that both changes of ictal and interictal PAC intensity can identify seizure onset zone or epileptogenic zone, predict the occurrence of epilepsy and surgical outcome. This paper will make a review of the application of PAC in the research of epilepsy from following aspects: the mechanism of PAC formation, the algorithm of PAC, physiological PAC, the relationships between pathological PAC with epileptogenic zone, to summarize the application of PAC in epilepsy research.