摘要
miR-203是近来研究发现的上皮特异性miRNA,通过调控靶mRNA转录后的表达,抑制角质形成细胞增殖潜能,诱导细胞周期退出和细胞分化,在上皮相关疾病中发挥重要作用。HPV通过抑制miR-203,调控下游靶基因以调节病毒生命周期。本文就miR-203的生物学特性,调控靶基因p63、survivin、细胞因子信号转导抑制因子3(SOCS3)在HPV感染中的作用以及与宫颈癌、尖锐湿疣和口咽癌等相关疾病的研究进展作一综述。
miR-203 is an epithelial-specific miRNA in recent research.It plays a critical role in epithelial diseases by regulating post-transcriptional expression of target mRNA,inhibiting the proliferative potential of keratinocytes and leading to the induction of cell cycle withdrawal and cell differentiation.Human papillomavirus(HPV)adjusts the viral life cycle by inhibiting miR-203 and regulating downstream target genes.This review focuses on the biological characteristics of miR-203,regulation of target genes such as p63,survivin,suppressor of cytokine signaling 3(SOCS3)in HPV infection and especially its role in research of cervical cancer,condyloma acuminatum and oropharyngeal carcinoma.
作者
吴扬帆
卜璋于
Wu Yangfan;Bu Zhangyu(The Fourth Clinical Medical School of Zhejiang University of Traditional Chinese Medicine,Department of Dermatology,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)
出处
《国际流行病学传染病学杂志》
CAS
2020年第4期354-357,共4页
International Journal of Epidemiology and Infectious Disease
基金
浙江省医药卫生科技计划(2018KY578、2020RC095)
浙江省公益技术应用研究计划(LGF19H110001)
杭州市社会发展科研自主申报项目(20191203B94)。
