NLR指导奥拉西坦与血栓通治疗急性脑梗死的作用分析

Role of NLR in guiding oxiracetam and Xueshuantong in the treatment of acute cerebral infarction

目的探讨中性粒细胞与淋巴细胞比值(NLR)指导奥拉西坦与血栓通治疗脑梗死的作用。方法 60例急性脑梗死患者,治疗前所有患者均进行NLR计算,根据NLR不同分为高NLR组(NLR≥3.48)和低NLR组(NLR<3.48),各30例。所有患者均给予奥拉西坦与血栓通治疗。比较两组临床疗效及治疗前后美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数。结果低NLR组患者的临床总有效率为90.00%,明显高于高NLR组的66.67%,差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分和Barthel指数均优于本组治疗前,且低NLR组NIHSS评分(5.99±1.23)分和Barthel指数(75.55±5.12)分明显优于高NLR组的(7.84±2.01)、(55.12±4.98)分,差异具有统计学意义(P<0.05)。结论 NLR指导奥拉西坦与血栓通治疗急性脑梗死具有重要价值,可间接反映药物治疗的疗效和患者预后。

Objective To discuss the role of neutrophil to lymphocyte ratio(NLR)in guiding oxiracetam and Xueshuantong in the treatment of acute cerebral infarction.Methods There were 60 cases of acute cerebral infarction,and all patients were calculated for NLR before treatment.They were divided into high-NLR group(NLR≥3.48)and low-NLR group(NLR<3.48)according to NLR,with 30 cases in each group.All patients were treated with oxiracetam and Xueshuantong.The clinical efficacy,National Institutes of Health stroke scale(NIHSS)score and Barthel index before and after treatment were compared between the two groups.Results The total clinical effective rate of low-NLR group was 90.00%,which was obviously higher than that of high-NLR group 66.67%,and the difference was statistically significant(P<0.05).After treatment,NIHSS score and Barthel index of the two groups was better than that before treatment,and NIHSS score(5.99±1.23)points and Barthel index(75.55±5.12)points of low-NLR group was obviously better than that of high-NLR group(7.84±2.01)and(55.12±4.98)points,and the difference was statistically significant(P<0.05).Conclusion NLR has important value in guiding oxiracetam and Xueshuantong in the treatment of acute cerebral infarction,and can indirectly reflect the efficacy of drug treatment and patient prognosis.