五苓散联合复方樟柳碱注射液对中心性浆液性脉络膜视网膜病变患者WBV、PV、RBC的影响

Influence of Modified Wuling Powder Combined with Compound Camphorine Injection on WBV,PV and RBC of Patients with Central Serous Chorioretinopathy

目的研究五苓散加减联合复方樟柳碱注射液对中心性浆液性脉络膜视网膜病变患者WBV、PV、RBC的影响.方法选取2018年11月—2019年10月103例中心性浆液性脉络膜视网膜病变患者进行前瞻性研究,按照随机综合平衡法,划分A组(51例,复方樟柳碱注射液)和B组(52例,五苓散加减联合复方樟柳碱注射液),比较2组治疗前与治疗1个月后视力与光敏度情况;治疗1个月临床疗效、治疗前与治疗1个月后血液流变学指标:WBV、PV、RBC变化情况;治疗期间2组不良反应情况.结果与治疗前相比,治疗1个月后2组患者的视力与光敏度均明显提升,且B组高于A组(P<0.05);治疗1个月后,B组临床治疗总有效率98.08%高于A组84.31%(P<0.05);与治疗前相比,治疗后2组患者的WBV、PV、RBC水平明显降低,且B组低于A组(P<0.05);B组患者视线模糊、皮下瘀血等不良反应总发生率为3.85%,低于A组的17.65%(P<0.05).结论应用五苓散加减联合复方樟柳碱注射液治疗中心性浆液性脉络膜视网膜病变,提高患者视力,改善眼部光敏感度,增强临床疗效,改善患者WBV、PV、RBC等血液流变学指标,减少不良反应的发生,具有较高的安全性.

Objective To investigate the effects of modified Wuling powder combined with compound camphorine injection on WBV, PV and RBC of patients with central serous chorioretinopathy. Methods A prospective study was conducted on 103 patients with central serous chorioretinopathy from November 2018 to October 2019. According to the random comprehensive balance method, they were divided into group A(n=51, compound anisodine injection) and group B(n=52, modified Wuling powder combined with compound camphorine injection). Visual acuity and light acuity before and after 1 month of treatment, the clinical effect, hemorheology indexes before and after 1 month of treatment: changes of WBV, PV and RBC, adverse reactions of the two groups during treatment were compared between the two groups. Results Compared with before treatment, the visual acuity and photosensitivity of the patients in the two groups were significantly improved after 1 month of treatment, and group B was higher than group A(P<0.05). After 1 month of treatment, the total effective rate of group B was 98.08% higher than 84.31% of group A(P<0.05). Compared with before treatment, WBV, PV and RBC levels in the two groups were significantly lower after treatment, and group B was lower than group A(P<0.05). The incidence of adverse reactions such as blurred vision and subcutaneous blood stasis in group B was 3.85% lower than 17.65% in group A(P<0.05). Conclusion Modified Wuling powder combined with compound camphorine injection in the treatment of central serous chorioretinopathy can improve the patients’ vision, improve the light sensitivity of the eyes, enhance the clinical effect, improve the hemorheology indexes such as WBV, PV, RBC, and reduce the occurrence of adverse reactions, which has a high safety.