摘要
Functional electrical stimulation is an effective way to rebuild hindlimb motor function after spinal cord injury.However,no site map exists to serve as a reference for implanting stimulator electrodes.In this study,rat models of thoracic spinal nerve 9 contusion were established by a heavy-impact method and rat models of T6/8/9 spinal cord injury were established by a transection method.Intraspinal microstimulation was performed to record motion types,site coordinates,and threshold currents induced by stimulation.After transection(complete injury),the core region of hip flexion migrated from the T13 to T12 vertebral segment,and the core region of hip extension migrated from the L1 to T13 vertebral segment.Migration was affected by post-transection time,but not transection segment.Moreover,the longer the post-transection time,the longer the distance of migration.This study provides a reference for spinal electrode implantation after spinal cord injury.This study was approved by the Institutional Animal Care and Use Committee of Nantong University,China(approval No.20190225-008)on February 26,2019.
基金
supported by the National Natural Science Foundation of China,No.61534003(to ZGW),81371663(to XYS)
Opening Project of State Key Laboratory of Bioelectronics in Southeast University(to XYS)
the“226 Engineering”Research Project of Nantong Government(to XYS)
“Six Talent Peaks”Project,No.SWYY-116(to XYS)
Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX18_2424(to CLT)。
