雷公藤多苷、来氟米特、环磷酰胺治疗原发性IgA肾病的疗效对比

Comparison of the Efficacy of Tripterygium Wilfordii Polyglycoside,Leflunomide and Cyclophosphamide in the Treatment of Primary IgA Nephropathy

目的:比较不同免疫抑制剂治疗IgAN的临床疗效。方法:将符合相应标准的129例IgAN患者分入TW组、LEF组、CTX组各43例,TW组给予患者TW,LEF组给予患者LEF,CTX组给予患者CTX。结果:在完全缓解与总有效方面,与LEF组和CTX组相比,TW组更优秀(P<0.05);在消化道反应与不良反应总发生率方面,与CTX组相比,TW组与LEF组均较少(P<0.05)。结论:采用TW作为免疫抑制剂治疗IgAN的临床疗效更为显著,且副作用较低,更为安全。

Objective:To compare the clinical efficacy of different immunosuppressive agents in the treatment of IgAN.Methods:129 IgAN patients who met the corresponding criteria were divided into TW group,LEF group,and CTX group,with 43 cases in each group.TW group was given TW,LEF group was given LEF,and CTX group was given CTX.Results:In terms of complete remission and total effectiveness,the TW group was better than the LEF group and the CTX group(P<0.05);In terms of the total incidence of digestive tract reactions and adverse reactions,the LEF group was less than the CTX group and the TW group(P<0.05).Conclusion:The clinical efficacy of TW as an immunosuppressive agent in the treatment of IgAN is more significant,which is safer,with lower side effects.