吉西他滨灌注治疗膀胱癌的临床效果分析

Clinical Effect of Gemcitabine Perfusion in the Treatment of Bladder Cancer

目的:研究吉西他滨灌注治疗膀胱癌的临床效果。方法:选取2016年6月~2019年1月时间段内某院收治的进行膀胱癌诊治的患者48例作为研究对象,随机将其分为研究组与对照组各24例。研究组于TUR-BT术后立即向灌注吉西他滨进行治疗,对照组患者在术后立即灌注常规性治疗膀胱癌的药物如吡柔比星,观察两组患者TUR-BT术后灌注药物以后疾病的复发情况,以及治疗期间出现的不良反应率,并研究统计两年以后患者生存率及复发率。结果:研究组患者不良反应发生率明显低于对照组(P<0.05),研究组患者术后灌注药物两年后复发率及生存率明显优于对照组(P<0.05)。结论:吉西他滨进行膀胱灌注的临床效果显著,而且不良反应少,不仅能减轻患者所承受的痛苦,更能提高患者的生存率,因此值得在临床中广泛应用推广。

Objective:To study the clinical effect of gemcitabine perfusion in the treatment of bladder cancer.Methods:A total of 48 patients with bladder cancer admitted to a hospital from June 2016 to January 2019 were selected as study subjects.They were randomly divided into study group and control group,with 24 patients in each group.Patients in the study group were treated with gemcitabine perfusion immediately after TUR-BT.Patients in the control group were immediately perfusion with conventional drugs for bladder cancer such as piriloxacin.The disease recurrence after perfusion of TUR-BT,incidence of adverse reaction rate during treatment,and the survival rate and recurrence rate after two years in the two groups were statistically analyzed and observed.Results:The incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05),and the recurrence rate and survival rate after two years in the study group were significantly better than those in the control group(P<0.05).Conclusion:In this study,gemcitabine has significant clinical effect on bladder perfusion with few adverse reactions,which can not only alleviate the pain suffered by patients,but also improve the survival rate of patients.Therefore,it is worthy of wide application and promotion in clinical practice.