镇静状态下肺泡灌洗氨溴索对重症肺炎患者呼吸功能及血清炎症因子水平的影响

Effects of Alveolar Lavage Ambroxol on Respiratory Function and Serum Inflammatory Factors in Patients with Severe Pneumonia under Sedation

目的:探讨镇静状态下肺泡灌洗氨溴索对重症肺炎患者呼吸功能及血清炎症因子水平的影响。方法:选取2017年1月~2019年1月期间某院收治重症肺炎患者60例,随机分为观察组和对照组。观察组患者在镇静状态下行床边纤维支气管镜氨溴索肺泡灌洗治疗,对照组患者予以常规综合治疗,比较两组患者治疗前后呼吸功能指标、血清炎性因子水平及临床疗效。结果:治疗后,观察组患者FEV1、PEF和FVC水平均高于对照组(P<0.05),观察组CRP和IL-6水平均低于对照组(P<0.05),观察组患者治疗有效率90.00%高于对照组(P<0.05)。结论:镇静状态下肺泡灌洗氨溴索可降低重症肺炎患者血清炎症因子水平,改善肺部呼吸功能,临床效果显著。

Objective:To investigate the effect of alveolar lavage ambroxol on respiratory function and serum inflammatory factors in patients with severe pneumonia under sedation.Methods:60 patients with severe pneumonia in a hospital from January 2017 to January 2019 were selected and randomly divided into observation group and control group.The patients in the observation group were given ambroxol alveolar lavage by bedside fiberoptic bronchoscope under sedation,while the patients in the control group were given routine comprehensive treatment.Then the respiratory function,serum inflammatory factors and the clinical efficacy were compared between the two groups before and after treatment.Results:After treatment,the levels of FEV1,PEF and FVC in the observation group were higher than those in the control group(P<0.05).The levels of CRP and IL-6 in the observation group were lower than those in the control group(P<0.05).The effective rate of treatment in the observation group was 90.00%,which was higher than that in the control group(P<0.05).Conclusion:Under sedation,alveolar lavage ambroxol can reduce the level of serum inflammatory factors and improve lung respiratory function in patients with severe pneumonia,with remarkable clinical effect.