丙戊酸钠、左乙拉西坦治疗小儿癫痫的疗效差异

Difference of Therapeutic Effect of Sodium Valproate and Lvetiracetam on Epilepsy in Children

目的:分别使用丙戊酸钠、左乙拉西坦对癫痫患儿进行治疗,比较其疗效差异。方法:抽取某院在2017年1月~2019年1月之间收治的40例癫痫患儿,随即将其分为对照组与观察组,对照组患儿采用左乙拉西坦治疗,观察组患儿采用丙戊酸钠治疗,比较两组患儿治疗总有效率与不良反应发生率。结果:观察组患儿治疗总有效率95.0%明显高于对照组70.0%,两组数据对比差异显著(P<0.05);观察组患儿不良反应发生率5.0%低于对照组10.0%,两组数据对比无明显差异(P>0.05)。结论:丙戊酸钠与左乙拉西坦用于治疗小儿癫痫均安全可靠,其中丙戊酸钠的临床疗效更为确切,可作为小儿癫痫治疗的首选药物。

Objective:To compare the efficacy of sodium valproate and levetiracetam in the treatment of children with epilepsy.Methods:40 cases of patients with epilepsy treated in a hospital from January 2017 to January 2019 were selected and divided into control group and observation group.The control group was treated with levetiracetam,while the observation group was treated with sodium valproate.The total effective rate and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group(95.0%)was higher than that of the control group(70.0%),the difference between the two groups was significant(P<0.05);The incidence of adverse reactions in the observation group(5.0%)was lower than that in the control group(10.0%),the difference between the two groups was no significant(P>0.05).Conclusion:Both sodium valproate and levetiracetam are safe and reliable in the treatment of epilepsy in children,among which sodium valproate is more effective and can be used as the first choice for the treatment of epilepsy in children.