Neuropilins在肿瘤中的多功能作用机制

Multifunctional mechanism of neuropilins in tumor

神经纤毛蛋白(NRPs)是一种调控胚胎组织发育、体内稳态以及癌症进展的跨膜糖蛋白。这篇综述讨论NRPs在各种癌症中的功能及其潜在机制,重点是NRPs在多功能细胞因子转化生长因子⁃β1(TGF⁃β1)信号传导途径、上皮⁃间质转化(EMT)、癌症干细胞(CSC)特性和药物抵抗调节中的作用,探讨NRPs调节作用如何促进细胞可塑性、肿瘤进展及转移。最后,讨论了NRPs在靶向治疗中的广泛应用前景。

Neuropilins(NRPs)are transmembrane glycoproteins that regulates embryo tissue develop⁃ment,homeostasis,and cancer progression.The purpose of this review article is to discuss the function and potential mechanism of NRPs in various cancers,especially in the multifunctional cytokine trans⁃forming growth factor-β1(TGF-β1)signaling pathway and Epithelial⁃Mesenchymal Transition(EMT).The characteristics of cancer stem cells(CSC)and the role of drug resistance regulation,explore how NRPs regulation can promote cell plasticity,tumor progression and metastasis.Finally,discuss the broad application prospects of NRPs in targeted therapy.