埃索美拉唑治疗阿司匹林相关性胃肠黏膜损伤的效果分析

The Effect of Esomeprazole in the Treatment of Aspirin Related Gastrointestinal Mucosal Injury

目的分析埃索美拉唑治疗阿司匹林相关性胃肠黏膜损伤的临床效果。方法选择2018年7月—2019年5月我院收治的102例阿司匹林相关性胃肠黏膜损伤患者作为分析对象,按治疗方式的不同将其分为对比组(予以奥美拉唑治疗)和研究组(予以埃索美拉唑治疗),每组51例。比较两组治疗前后的胃蛋白酶原(PG)、促胃液素17水平及治疗总有效率、幽门螺杆菌(Helicobacter pylori,Hp)根治率、不良反应发生率。结果治疗前,两组的胃蛋白酶原Ⅰ(pepsinogenⅠ,PGⅠ)、胃蛋白酶原Ⅱ(pepsinogenⅡ,PGⅡ)及促胃液素17水平无统计学差异(P>0.05);经治疗,研究组的PGⅠ、PGⅡ及促胃液素17水平均低于对比组(P<0.05);研究组的治疗总有效率(96.08%)高于对比组(78.43%),研究组的Hp根治率(92.16%)高于对比组(74.51%),研究组的不良反应发生率(5.88%)低于对比组(19.61%),差异有统计学意义(P<0.05)。结论采用埃索美拉唑治疗阿司匹林相关性胃肠黏膜损伤患者,能明显修复阿司匹林引起的胃肠黏膜损伤,帮助患者消除Hp,且该药的不良反应较低,疗效显著。

Objective To analyze the clinical effect of Esomeprazole in the treatment of aspirin related gastrointestinal mucosal injury.Methods From July 2018 to May 2019,102 patients with aspirin related gastrointestinal mucosal injury in our hospital were selected as the analysis objects.According to the different treatment methods,they were divided into the control group(treated with omeprazole)and the study group(treated with esomeprazole),51 cases in each group.The levels of pepsinogen(PG),gastrin 17,the total effective rate,the radical cure rate of Helicobacter pylori(Hp)and the incidence of adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in the levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and gastrin 17 between the two groups(P>0.05);after treatment,the levels of PGⅠ,PGⅡand gastrin 17 in the study group were lower than those in the control group(P<0.05);the total effective rate of the study group(96.08%)was higher than that of the control group(78.43%).The Hp radical cure rate(92.16%)in the study group was higher than that in the control group(74.51%),and the incidence of adverse reactions in the study group(5.88%)was lower than that in the control group(19.61%),P<0.05.Conclusion Esomeprazole can obviously repair the gastrointestinal mucosa damage caused by aspirin and help the patients to eliminate Hp.The adverse reactions of esomeprazole are low and the curative effect is significant.