纤维支气管镜吸痰联合抗感染治疗重症肺炎患者的效果

Effects of fiberoptic bronchoscope sputum suction combined with anti-infection in treatment of patients with severe pneumonia

目的:观察纤维支气管镜吸痰联合抗感染治疗重症肺炎患者的效果。方法:选取120例重症肺炎患者为研究对象,采用随机数字表法分为对照组与观察组各60例,对照组采用单纯抗感染治疗,观察组在对照组基础上联合纤维支气管镜吸痰治疗。比较两组肺功能指标水平、血气分析指标水平和炎性因子水平。结果:治疗后,两组肺总量(TLC)、最大通气量(MMV)、第一秒用力呼气量(FEV1)和功能残气量(FRC)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组氧合指数(PaO2/FiO2)、血氧饱和度(SaO2)和动脉氧分压(PaO2)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组C反应蛋白(CRP)、白细胞介素-6(IL-6)、血清降钙素原(PCT)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:纤维支气管镜吸痰联合抗感染治疗重症肺炎患者可提高肺功能和血气分析指标水平,以及降低炎性因子水平的效果优于单纯抗感染治疗效果。

Objective:To explore effects of fiberoptic bronchoscope sputum suction combined with anti-infection in treatment of patients with severe pneumonia.Methods:120 patients with severe pneumonia were selected as the research objects,and were divided into control group and observation group by using the random number table,60 cases in each group.The control group was treated with single anti-infective treatment,while the observation group was treated with fiberoptic bronchoscope sputum suction combined with anti-infective treatment.Then,the levels of lung function indexes,inflammatory factors and blood gas indexes were compared between the two groups.Results:After the treatment,total lung capacity(TLC),maximum voluntary ventilation(MMV),forced expiratory volume in 1 second(FEV1)and functional residual capacity(FRC)levels in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).The oxygenation index(PaO2/FiO2),blood oxygen saturation(SaO2)and arterial partial pressure of oxygen(PaO2)levels in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).The levels of C-reactive protein(CRP),interleukin-6(IL-6)and serum procalcitonin(PCT)in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).Conclusions:Fiberoptic bronchoscope sputum suction combined with anti-infection in the treatment of the patients with severe pneumonia can increase the levels of lung function indicators and blood gas indicators and reduce the levels of inflammatory factors.Moreover,it is superior to single anti-infective treatment.