霉酚酸类药物在器官移植受者中的药代动力学研究进展

Research progress on pharmacokinetics of mycophenolic acid drugs in organ transplant recipients

霉酚酸(MPA)类药物是器官移植受者常用的免疫抑制剂,具有良好的免疫抑制效果,但用药不足或过量均不利于受者预后,需要准确控制给药剂量。MPA的代谢具有较大个体差异,因此这类药物的代谢规律、监测手段在临床上具有重要意义。本文综述了近5年MPA类药物在器官移植受者中代谢规律的研究进展,归纳了药物代谢规律和监测手段研究的主要结果和方向,对器官移植中MPA类药物代谢的研究进行了简要的回顾和展望。

Mycophenolic acid(MPA)drugs are common immunosuppressant for organ transplant recipients,which possesses high immunosuppressive effect.However,insufficient or excessive dosage of MPA is not conducive to clinical prognosis of the recipients.Hence,it is necessary to accurately control the dosage of MPA.The metabolism of MPA significantly differs among individuals.The metabolic pattern and monitoring method of these drugs are of important significance in clinic.In this article,the research progresses on the metabolism of MPA drugs in organ transplant recipients in recent five years were reviewed,the main results and direction of drug metabolism and monitoring methods were summarized,and the researches on the metabolism of MPA drugs in organ transplantation were briefly reviewed and prospected.