多奈哌齐与利培酮联合盐酸美金刚治疗血管性痴呆伴精神行为症状患者的疗效

Efficacy of Donepezil and Risperidone Combined with Memantine Hydrochloride in the Treatment of Patients with Vascular Dementia with Psychobehavioral Symptoms

目的探讨多奈哌齐与利培酮联合盐酸美金刚治疗血管性痴呆伴精神行为症状患者的疗效。方法选取2017年4月至2019年10月抚顺市第二医院收治的血管性痴呆伴精神行为症状患者66例作为研究对象,随机分为对照组与观察组,各33例。对照组予以利培酮联合盐酸美金刚治疗,观察组予以多奈哌齐联合盐酸美金刚治疗。比较两组临床疗效、精神行为[阿尔茨海默病理行为量表(BEHAVE-AD)评分]、认知功能[蒙特利尔认知评估量表(MoCA)评分]情况及不良反应。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组BEHAVE-AD评分(8.28±3.05)分低于对照组(10.52±3.41)分,MoCA评分(29.06±1.48)分高于对照组(27.92±1.76)分,差异有统计学意义(P<0.05);观察组不良反应发生率(9.09%)略低于对照组(15.15%),但差异无统计学意义(P>0.05)。结论伴精神行为症状的血管性痴呆患者应用多奈哌齐与利培酮联合盐酸美金刚治疗可获得较为满意的效果,而多奈哌齐联合盐酸美金刚疗效更佳,可有效改善患者的精神行为症状及认知功能,不良反应少,用药安全性高。

Objective To explore the effects of donepezil and risperidone combined with memantine hydrochloride in the treatment of patients with vascular dementia with psychobehavioral symptoms. Methods A total of 66 patients with vascular dementia admitted to Fushun Second Hospital from April 2017 to October 2019 were randomly divided into a control group and an observation group, with 33 cases in each group. The control group was treated with risperidone and memantine hydrochloride, while the observation group was treated with donepezil and memantine hydrochloride. Clinical efficacy, mental behavior(BEHAVE-AD score), cognitive function(MoCA score) and adverse reactions were compared between the 2 groups. Result After treatment, the therapeutic effects of the observation group was better than that of the control group, with a statistically significant difference(P<0.05);after treatment, the BEHAVE-AD score of the observation group(8.28±3.05) was lower than that of the control group(10.52±3.41), and the MOCA score(29.06±1.48) was higher than that of the control group(27.92±1.76), with a statistically significant difference(P<0.05);the incidence of adverse reactions was(9.09%), which was slightly lower than that of the control group(15.15%), but the difference was not significant(P>0.05). Conclusion Donepezil and risperidone combined with memantine hydrochloride can achieve satisfactory results in the treatment of patients with vascular dementia and psychobehavioral symptoms, while donepezil combined with memantine hydrochloride is more effective, which can further improve the psychobehavioral symptoms and cognitive function of patients, with fewer adverse reactions and high safety.