中医疗法治疗慢性肾衰竭伴急性痛风性关节炎患者的临床疗效

Clinical Effects of the Treatment of Patients with Chronic Renal Failure with Acute Gouty Arthritis by Traditional Chinese Medicine

目的探讨中医疗法治疗慢性肾衰竭伴急性痛风性关节炎(AGA)患者的临床疗效。方法选取2016年6月至2018年6月深圳市中医院收治的慢性肾衰竭伴AGA患者80例作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。两组给予慢性肾衰竭基础治疗,同时对照组口服双氯芬酸钠双释放肠溶胶囊,观察组采用中医疗法,予以口服加味四妙散及外敷清热消肿膏。1周为1个疗程,治疗1个疗程后比较两者患者的治疗效果。结果治疗后,两组症状[视觉模拟评分法(VAS)、关节肿胀]评分及体征(关节活动)评分较同组治疗前下降(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后,两组尿酸(UA)、C反应蛋白(CRP)、红细胞沉降率(ESR)较同组治疗前下降(P<0.05),且观察组UA、CRP、ESR低于对照组(P<0.05)。治疗后,观察组肌酐(Scr)低于对照组,内生肌酐清除率(Ccr)高于对照组,差异有统计学意义(P<0.05)。观察组治疗有效率87.5%优于对照组治疗有效率77.5%(P<0.05)。结论中医疗法(口服加味四妙散和外敷清热消肿膏)治疗慢性肾衰竭伴AGA的疗效肯定。

Objective To explore the effects of traditional Chinese medicine on patients with chronic renal failure with acute gouty arthritis. Methods A total of 80 patients with chronic renal failure with acute gouty arthritis admitted to Shenzhen Traditional Chinese Medicine Hospital were selected as the research objects and were divided into a control group and an observation group according to random number table, with 40 cases in each group. The 2 groups were given the basic treatment for chronic renal failure with acute gouty arthritis. Meanwhile, The control group was given Diclofenac Sodium Dual Release Enteric-coated Capsules. The observation group was treated with traditional Chinese medicine and given Jiawei Simiao Powder and Qingre Xiaozhong Cream. One week was a course of treatment. After one course of treatment, the clinical efficacy 2 groups of patients were compared. Results After treatment, the symptom [visual analog score(VAS), joint swelling]scores and physical signs(joint activity) scores of the 2 groups decreased compared with the same group before treatment(P<0.05), and the scores of the observation group were lower than those of the control group(P<0.05). After treatment, the uric acid(UA), C-reactive protein(CRP), and erythrocyte sedimentation rate(ESR) of the 2 groups decreased compared with the same group before treatment(P<0.05), and the UA, CRP, and ESR of observation group were lower than the control group(P<0.05). 0.05. After treatment, the creatinine(Scr) in the observation group was lower than the control group, and the endogenous creatinine clearance(Ccr) was higher than the control group, the difference was statistically significant(P<0.05). The treatment efficiency of the observation group was 87.5%, better than that of the control group 77.5%(P<0.05). Conclusion Traditional Chinese medicine method(Jiawei Simiao Powder and QingreXiaozhong Cream) is effective in treating chronic renal failure with acute gouty arthritis.