药源性皮疹与药物代谢的相关性研究

Advances in the Correlation Between Cutaneous Drug Eruptions and Drug Metabolism

严重的皮肤不良反应(severe cutaneous adverse reactions,SCARs)是一组包括多种类型皮肤损伤的迟发型超敏反应,通常由药物引起,在全球范围内引起了广泛关注。药源性皮疹是药物引起皮肤最常见的不良反应。近年来随着研究的深入,药源性皮疹发生的免疫病理学机制取得了一定的进展。与此同时,其发生发展的病因学机制也被逐步阐明,其中药物结构、代谢,病毒感染和遗传易感性与某些重型药源性皮疹密切相关。

Severe cutaneous adverse reactions(SCARs) are a group of delayed-type hypersensitivity reactions that include many types of skin damage, usually caused by drugs, and have attracted widespread attention worldwide. Drug-induced rash is the most common adverse reaction caused by drugs. With the deepening of research in recent years, the immunopathology mechanism of drug-induced rash has made some progress. At the same time, the etiological mechanism of its occurrence and development has been gradually elucidated. Among them, drug structure, metabolism, viral infection and genetic susceptibility are closely related to certain severe drug-induced rashes.