摘要
荧光-磁共振成像(MRI)双模态分子探针突破了单一分子影像探针在灵敏度以及软组织分辨率等方面的局限性,在诊断和治疗等医学领域具有良好的应用潜力。钆掺杂碳量子点(Gd-CDs)是一种典型的荧光-MRI双模态分子探针,因其优异的荧光性能、良好的核磁共振成像能力和生物相容性等优点,在肿瘤的靶向性成像和监控诊疗方面具有广泛的应用前景。本文综述了目前Gd-CDs的制备、性能及其在双模态成像应用的研究现状,并提出目前存在的问题和前景展望。
Fluorescence-magnetic resonance imaging(MRI)dual-modal molecular probes,which breaks through the limitation of single molecular imaging probes in terms of sensitivity and soft tissue resolution,has attracted tremendous attention in the fields of diagnosis and treatment.Gadolinium-doped carbon dots(Gd-CDs)is a typical fluorescence-MRI dual-modal molecular probe.With excellent optical properties,good MRI capability and low toxicity,Gd-CDs has a wide application prospect in tumor targeting imaging and treatment monitoring.This work summarizes the research status of the preparations,performance,and applications of Gd-CDs in bimodal imaging.Present problems and prospects are also put forward.
作者
马逸骅
陈琳
杨永珍
于世平
苏秀琴
MA Yihua;CHEN Lin;YANG Yongzhen;YU Shiping;SU Xiuqin(Imaging Department,Shanxi Medical University,Taiyuan 030001,Shanxi,P.R.China;Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,Shanxi,P.R.China;Department of Interventional Therapy,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,P.R.China)
出处
《影像科学与光化学》
CAS
2020年第5期763-770,共8页
Imaging Science and Photochemistry
基金
山西省优秀人才科技创新项目(201805D211001)
国家自然科学基金青年基金项目(51803148)资助。
关键词
荧光成像
磁共振成像
双模态分子探针
钆掺杂碳量子点
fluorescence imaging
magnetic resonance imaging
dual-modal molecular probes
gadolinium-doped carbon dots
