CTP评估肺癌病理参数及放化疗前后临床疗效的研究

Study on CTP Evaluation of Pathological Parameters of Lung Cancer and the Clinical Efficacy Before and After Radiotherapy and Chemotherapy

探讨CT灌注(CTP)评估肺癌病理参数及放化疗前后临床疗效的应用价值。以152例接受放化疗治疗的肺癌患者为研究对象,对不同肿瘤分型、不同肿瘤大小、放化疗治疗前后,以及不同肺癌缓解情况的血流量(BF)、血容量(BV)、对比剂到达峰值时间(TTP)和表面通透性(PS)4项CTP参数进行记录和分析。结果发现,小细胞肺癌的BF、BV、TTP和PS值最高,其次为腺癌,鳞癌最低(P<0.05)。体积≥40cm3、放化疗前及未缓解组的BF、BV、TTP和PS值分别高于体积<40cm3、放化疗后及缓解组肺癌患者(P<0.05)。说明CTP参数与肺癌的病理类型、肿瘤大小之间存在联系,并且放化疗治疗后及病情缓解的肺癌患者,其CTP参数值均有所下降。

To investigate the value of CT perfusion(CTP)in evaluating the pathological parameters of lung cancer and the clinical efficacy before and after radiotherapy and chemotherapy.152Patients with lung cancer treated with radiation and chemotherapy were chosen as the research object.Different CTP parameters,such as blood flow(BF),blood volume(BV),time to peak(TTP),permeability surface(PS)between the patients with different tumor type,tumor size,radiation and chemotherapy before and after treatment were recorded.Our research found that BF,BV,TTP and PS values were the highest in SCLC,followed by adenocarcinoma and squamous cell carcinoma(P<0.05).The values of BF,BV,TTP and PS in the groups with a volume 40cm3 before radiotherapy and chemotherapy and without remission were higher than those in the groups with a volume<40cm3,after radiotherapy and chemotherapy and in the remission group(P<0.05).Thus,CTP parameters were associated with the pathological type and tumor size of lung cancer,and the values of CTP parameters of patients after radiotherapy and chemotherapy and patients in remission are decreased.