微小RNA 155对骨免疫的调控及其在牙周炎中作用的研究进展

Regulation of osteoimmunology by MicroRNA 155 and research progress of its possible mechanism in periodontitis

牙周炎是以牙龈炎症和牙槽骨进行性破坏为特征的慢性感染性疾病,牙周菌斑微生物和宿主免疫反应之间的相互作用影响着疾病的过程和进展。骨免疫学作为一个新的交叉学科领域,主要研究骨骼系统和免疫系统之间的分子交互机制,与牙周炎的发生密切相关。微小RNA 155(miR-155)是一种真核生物内源性非编码RNA,可与目标基因mRNA的3'-非编码区结合而抑制其表达,参与机体的免疫、造血、炎症等生理或病理过程。大量研究表明,在牙周炎发展过程中miR-155的表达量发生改变,但目前文献报道的结果尚不一致,且miR-155还可通过多条途径参与骨骼系统的调控。本文对miR-155在骨免疫及牙周炎发生中的调节作用进行综述,以期为牙周炎的临床治疗提供新的思路和策略。

Periodontitis is a chronic infectious disease that is characterised by the inflammation of gingiva and the progressive destruction of alveolar bone.The interaction between plaque microbes and host defence affects the process of the disease.As a new interdisciplinary field,osteoimmunology mainly studies the molecular interaction mechanism between skeletal and immune systems,which are related to the occurrence of periodontitis.MicroRNA 155(miR-155)is an endogenous noncoding single-stranded RNA in eukaryotic organisms.miR-155 combines with the 3’-untranslated region of target mRNA to negatively regulate the expression of mRNA.miR-155 can participate in multiple physiological and pathological processes,such as immunity,haematopoiesis and inflammation.A large number of studies have shown that the expression level of miR-155 can be altered during periodontitis development,but results reported in literature are inconsistent.miR-155 can also regulate the skeletal system through multiple pathways.This review elaborates the modulation of miR-155 in osteoimmunology and periodontitis.We aim to offer novel insights and strategies for clinical therapy of periodontitis.