中药外敷配合Ⅰ期根除手术治疗肛周脓肿的临床效果

Clinical effect of external application of traditional Chinese medicine combined with phaseⅠeradication operation in the treatment of perianal abscess

目的探讨中药外敷配合Ⅰ期根除手术治疗肛周脓肿的临床效果。方法选取2018年10月~2019年10月我院收治的88例肛周脓肿患者,按照随机数字表法分为两组,每组各44例。所有患者均采取Ⅰ期根除手术,对照组术后进行常规治疗,研究组在对照组的基础上采取中药外敷治疗,持续治疗创面愈合为止。术后2周比较两组临床效果、实验室指标水平及康复效果。结果研究组的治疗总有效率(97.73%)高于对照组(81.82%),差异有统计学意义(P<0.05);两组术后当天实验室指标水平比较,差异无统计学意义(P>0.05);研究组术后2周的白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)为(17.96±5.92)、(94.93±17.42)ng/L,低于对照组的(22.05±7.38)、(106.46±19.21)ng/L,血管内皮生长因子(VEGE)为(4.38±0.62)ng/L高于对照组的[(3.59±0.53)ng/L,差异均有统计学意义(P<0.05);研究组术后疼痛持续时间、创面愈合时间及住院时间为(2.38±0.71)、(17.94±2.77)、(10.24±2.25)d,短于对照组的(3.62±0.75)、(21.83±3.59)、(12.24±2.63)d,差异均有统计学意义(P<0.05)。结论中药外敷配合Ⅰ期根除手术治疗肛周脓肿的效果显著,能改善患者炎症因子及生长因子水平,增强康复效果。

Objective To explore the clinical effect of external application of traditional Chinese medicine combined with phaseⅠeradication operation in the treatment of perianal abscess.Methods A total of 88 patients with perianal abscess admitted to our hospital from October 2018 to October 2019 were selected and divided into two groups according to the random number table method,44 cases in each group.All patients were treated with phaseⅠeradication operation,and the control group was treated with routine treatment.On this basis,the study group was treated with external application of traditional Chinese medicine until wound healing.Two weeks after operation,the clinical effect,laboratory index and rehabilitation effect of the two groups were compared.Results The total effective rate of the study group(97.73%)was higher than that of the control group(81.82%),the difference was statistically significant(P<0.05).There was no significant difference between the two groups on the same day after operation in the level of laboratory indicators(P>0.05);Interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)2 weeks after operation in study group were(17.96±5.92),(94.93±17.42)ng/L,lower than those in the control group of(22.05±7.38),(106.46±19.21)ng/L,vascular endothelial growth factor(VEGE)was(4.38±0.62)ng/L,higher than that in the control group of(3.59±0.53)ng/L,the differences were statistically significant(P<0.05).The duration of postoperative pain,wound healing time and hospitalization time in the study group were(2.38±0.71),(17.94±2.77),(10.24±2.25)d,shorter than those in the control group of(3.62±0.75),(21.83±3.59),(12.24±2.63)d,and the differences were statistically significant(P<0.05).Conclusion External application of traditional Chinese medicine combined with phaseⅠeradication surgery is effective in the treatment of perianal abscess,which can improve the level of inflammatory factors and growth factors,and enhance the rehabilitation effect.