糖尿病合并难治性高血压患者应用贝那普利治疗的临床观察

Clinical observation of benazepril in the treatment of diabetes mellitus complicated with refractory hypertension

目的研究应用贝那普利治疗糖尿病合并难治性高血压患者的临床效果。方法选取2017年1月至2018年12月在本院就诊的糖尿病合并难治性高血压患者80例,随机分为对照组与观察组,每组40例。对照组使用短效或长效胰岛素控制血糖,硝苯地平缓释片控制血压,观察组患者在对照组的基础上使用贝那普利进行治疗。比较两组患者治疗前和治疗后6个月血压(收缩压和舒张压)、血清胱抑素C(CysC)及糖化血红蛋白(HbAlc)水平。结果两组患者治疗后收缩压和舒张压均明显低于治疗前,且观察组收缩压和舒张压明显低于对照组(P<0.05)。观察组治疗后CysC和HbAlc水平明显低于对照组(P<0.05)。结论糖尿病合并难治性高血压使用贝那普利进行治疗,可更明显地降低患者血压,降低患者的CysC和HbAlc水平,疗效显著,值得临床推广运用。

Objective To study the clinical effect of benazepril in the treatment of diabetes mellitus complicated with refractory hypertension.Methods 80 patients with diabetes mellitus complicated with refractory hypertension who were treated in our hospital from January 2017 to December 2018 were randomly divided into control group and observation group,with 40 cases in each group.The control group used short-acting or longacting insulin to control blood sugar,and the nifedipine sustained-release tablets to control blood pressure.The observation group was treated with benazepril on the basis of the control group.The changes of blood pressure(systolic pressure and diastolic pressure),serum cystatin C(CysC)and glycosylated hemoglobin(HbAlc)were compared between the two groups before and 6 months after treatment.Results After treatment,the systolic and diastolic blood pressures in both groups were significantly lower than those before treatment,and the systolic and diastolic blood pressures in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of CysC and HbAlc in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Benazepril in the treatment of diabetes mellitus complicated with refractory hypertension can significantly reduce blood pressure and the levels of CysC and HbAlc in patients with diabetes mellitus.It has brought more significant clinical effects and improved prognosis,which is worthy of vigorous promotion.