心房颤动患者药物治疗与导管消融治疗对其心室率与转复率的影响

Effects of drug therapy and catheter ablation on ventricular rate and recovery rate in patients with atrial fibrillation

目的:探讨药物治疗与导管消融治疗对心房颤动患者心室率与转复率的影响。方法:选取2012年12月至2013年9月上海复旦大学附属中山医院收治的心房颤动患者165例,随机分成两组,对照组进行药物治疗,研究组则进行导管消融治疗。观察对比患者的心房颤动症状发生情况,窦性心率维持率在1个月、3个月、6个月、12个月的变化情况及终点事件的发生情况。结果:研究组的心房颤动症状的复发率(39.5%)低于对照组(66.7%,P<0.05);研究组的心窦性心率维持率1个月后(96.3%)、3个月后(90.1%)、6个月后(85.2%)、12个月后(77.8%)高于对照组(94.0%、75.0%、67.9%、53.4%,P<0.05);研究组的终点事件发生率(8.6%)与对照组(10.7%)无明显差异。结论:经皮导管消融术治疗心房颤动临床效果显著优于药物治疗,能显著降低临床症状的复发率和提高窦性心律维持率,显著改善患者的生活质量。

Objective:To explore the effects of drug therapy and catheter ablation on ventricular rate and recovery rate in patients with atrial fibrillation.Methods:From December 2012 to September 2013,165 patients with atrial fibrillation admitted to Zhongshan Hospital Affiliated to Fudan University were randomly divided into two groups.The occurrence of atrial fibrillation symptoms,changes of sinus rhythm maintenance rates at 1,3,6 and 12 months,and the occurrence of endpoint events were recorded and compared.Results:The recurrence rate of atrial fibrillation symptoms in the study group(39.5%)was lower than that in the control group(66.7%,P<0.05).The sinus rhythm maintenance rates of the study group were higher than those of the control group(94.0%,75.0%,67.9%,and 53.4%)after 1 month(96.3%),3 months(90.1%),6 months(85.2%),and 12 months(77.8%,P<0.05).There was no significant difference in the incidence of endpoint events between the study group(8.6%)and the control group(10.7%,P>0.05).Conclusions:The clinical effect of catheter ablation in the treatment of atrial fibrillation is significantly better than that of drug therapy,which can significantly reduce the recurrence rate of clinical symptoms,improve the maintenance of sinus rhythm and improve the quality of life of patients.