食源性天然产物对酒精性肝损伤的防护作用研究进展

Review on the Protective Effects of Food-Derived Natural Compounds on Alcohol-Induced Liver Injury

酒精性肝损伤是临床中较为常见的一类肝损伤,主要由长期或过量摄入酒精所引起。长期持续或短期剧烈的酒精性肝损伤会导致肝脏组织出现病变,继而可能会引发脂肪肝、肝炎、肝硬化,甚至肝癌。酒精性肝损伤已然成为全球关注的公共健康问题之一。因此,如何有效地防护酒精性肝损伤逐渐成为医药和功能食品领域的研究热点。近年来,具有低毒副作用、多途径、多靶点作用优势的天然产物备受关注;多种食源性天然产物已被报道具有防护酒精性肝损伤的作用。本文主要综述了酒精性肝损伤的主要发病机制和食源性天然产物防护酒精性肝损伤的相关研究进展,以期为进一步开展酒精性肝损伤的防护研究工作以及开发新型保肝药物和功能食品提供参考。

Alcohol-induced liver injury(AILI)is a clinically common type of liver injury that is mainly caused by long-term excessive intake of alcohol.Sustained or severe alcohol liver injury can cause pathological changes to liver tissues,which may develop into fatty liver,hepatitis,cirrhosis,or even liver cancer.AILI has become one of the major global public health concerns.Therefore,how to effectively protect against AILI is gradually becoming the focus of research in the fields of medicine and functional foods.In recent years,natural compounds with the advantages of low side effects and multiple pathways of action and targets have attracted considerable attention.A variety of food-derived natural compounds have been reported for their hepatoprotective activities against AILI.In this article,we review the main pathogenesis of AILI and the protective effects of food-derived natural compounds on AILI,which will hopefully provide a theoretical rationale for further research to prevent AILI and develop new hepatoprotective drugs or functional foods.