北京市通州区0~19岁健康人群流行性腮腺炎抗体水平分析

Mumps antibody level in healthy population at ages of 0~19 years in Tongzhou District,Beijing

目的分析北京市通州区健康人群流行性腮腺炎(简称流腮)抗体水平,为流腮的防控提供科学依据。方法采用随机抽样的原则抽取通州区10个居委会作为调查点,选择在当地连续居住6个月以上的0~19岁健康人群为调查对象,通过问卷调查、查阅预防接种证和北京市免疫规划信息管理系统收集研究对象基本信息和疫苗免疫史,采用ELISA法检测血清流腮IgG抗体。结果共调查481人,总流腮IgG抗体阳性率为65.70%(316/481),浓度中位数为50.02 IU/L,各年龄组抗体阳性率在4.95%~91.2%之间,浓度中位数在3.51~109.47 IU/L之间。抗体水平最低的为0~8月组,最高为5~9岁组,抗体水平呈先升高后降低的趋势。不同年龄间抗体水平差异有统计学意义(P<0.05)。有免疫史人群抗体水平高于无免疫史人群(P<0.05)。结论北京市通州区18月~15岁人群流腮抗体水平较高,需重点关注15岁以上人群,推荐在高中时期加强接种1剂流腮疫苗。

Objective To determine the antibody level against mumps virus(MuV)in healthy population in Tongzhou District,Beijing and provide a scientific basis for prevention and control of mumps.Methods Healthy people at ages of0~19 years in 10 communities,who lived there for 6 months or more,were selected by randomly sampling and investigated by questionnaire,of whom the vaccination certificates of the peoples were checked up,the basic data and vaccination history were collected from Beijing Immunization Program Information Management System,and blood samples were collected and determined for IgG against MuV by ELISA.Results A total of 481 people were investigated,of whom the total positive rate of MuV IgG was 65.70%(316/481),the median concentration of MuV IgG was 50.02 IU/L.The positive rates of MuV-IgG in various age groups ranged from 4.95%to 91.2%,while the median concentrations from3.51 to 109.47 IU/L.The antibody level was the lowest in the age group of 0~8 months,while was the highest in the age group of 5~9 years,which showed increasing tendency at first then decreased.The antibody levels in various age groups showed significant difference(P<0.05),which was higher in the people with vaccination history than in that without vaccination history(P<0.05).Conclusion The mumps antibody level in the population at ages of 18 months^15 years in Tongzhou District was high,so the people at ages of more than 15 years need to be paid more attention.A booster dose of mumps vaccine is recommended to the people at high school age.