腹横肌平面阻滞对结直肠癌患者术后疼痛程度及炎性介质的影响

Influence of Transversus Abdominis Plane Block on Inflammatory Factors and Pain Degree of the Patients Underwent Colorectal Cancer Surgery

为探讨腹横肌平面阻滞(TAPB)对结直肠癌患者术后疼痛程度及炎性介质的影响,选取2017年5月至2019年3月行腹腔镜结直肠癌切除术患者50例,其中采用超声引导下腹横肌平面阻滞25例(TAPB组),硬膜外镇痛25例(PCEA组)。观察2组患者术后4h、12h、24h静息VAS评分以及白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)水平变化。结果显示,术后4h、12h、24hTAPB患者VAS评分显著低于PCEA组,差异具有统计学意义(P <0.05);术后4h、12h、24hTAPB组患者IL-6、TNF-α、CRP水平低于PCEA组,差异具有统计学意义(P <0.05)。结果表明,腹横肌平面阻滞可减轻结直肠癌患者疼痛和全身炎症反应。

This study was to investigate in influence of transversus abdominis plane block(TAPB)on inflammatory factors and pain degree of the paitents underwent colorectal cancer surgery,enrolled 50 patients with colorectal cancer who had received laparoscopic resection(2017-05-2019-03)and divided them into TAPB group(25 cases,adopted TAPB under ultrasound guideline)and PCEA group(25 cases,epidural analgesia);then,observed both group’s resting VAS score ratings at 4,12,and 24 hrs after surgery,as well as the level change of IL-6,of TNF-α,and of CRP.As results,at 4,12,and 24 hrs after surgery VAS score ratings as well as the level of IL-6,of TNF-α,and of CRP of TAPB groups’ patients were all significantly lower than that of PCEA groups’ patients(P <0.05).Results show that TAPB can reduce patients’ pain degree and systemic inflammmatory response.