兰州市人群甲状腺结节与甲状腺功能相关性分析

Analysis of correlation between thyroid nodules and thyroid function among people in Lanzhou

目的调查兰州市正常体检人群甲状腺结节情况,了解其流行病学特点及与甲状腺功能的相关性。方法选取2015年4月—2016年3月进行甲状腺彩超和甲状腺功能检测的兰州市人群共9 464名,对其性别、年龄、甲状腺功能等数据进行统计分析。结果该人群甲状腺结节总检出率为27.7%,女性检出率高于男性(χ^2=37.490,P<0.05)。该人群甲状腺结节检出率均随年龄增加呈上升趋势(χ^2=513.8,P<0.01)。人群甲状腺功能异常总体发生率为8.58%。甲状腺结节阳性人群功能异常率(12.00%)高于阴性人群(6.50%)(χ^2=73.86,P<0.05)。在甲状腺结节阳性人群中,女性促甲状腺激素(TSH)水平升高率(13.6%)高于男性(8.97%)(χ^2=12.63,P<0.05)。结论兰州市甲状腺结节发病率较高,应将甲状腺超声与甲状腺功能检测纳入常规体检项目,并关注28岁以上、TSH水平较高的女性等甲状腺结节高发人群。

Objective To investigate the incidence of thyroid nodules among normal physical examination people in Lanzhou and to understand the epidemiological features of thyroid nodules and its correlation with thyroid function. Methods A total of 9464 people who had been detected by thyroid color ultrasound and thyroid function tests were selected in Lanzhou from April 2015 to March 2016. The data of gender, age and thyroid function were analyzed statistically.Results The overall positive rate of thyroid nodules was 27.7%. The detection rate of female was higher than that of male(χ^2=37.490, P<0.05). The detection rate of thyroid nodules among the population increased with age(χ^2=513.8,P<0.01). The overall incidence rate of thyroid dysfunction was 8.58%. The abnormal rate of thyroid nodules in positive group(12.00%) was higher than that in negative group(6.50%,χ^2=73.86, P<0.05). In the group with positive thyroid nodules, the increase rate of thyroid stimulating hormone(TSH)in female(13.6%) was higher than that in male(8.97%, χ^2=12.63, P<0.05). Conclusion The incidence rate of thyroid nodules among the people in Lanzhou is high. Thyroid color ultrasound and thyroid function tests should be included into routine physical examination. Over 28 years old females with a high level of TSH are the high-risk group of thyroid nodules, who should be paid much more attention.