泮托拉唑对AMI后消化道出血患者血清PGE2的影响

Effect of Pantoprazole on Serum PGE in Patients with Gastrointestinal Hemorrhage after AMI

目的:分析泮托拉唑对急性心肌梗死(AMI)后消化道出血患者血清前列腺素E2(PGE2)的影响。方法:选择2018年6月-2019年8月本院收治的60例AMI后消化道出血患者为研究对象,应用随机数字表法将其分成参照组与试验组,每组30例。在常规对症治疗基础上,参照组采用奥美拉唑治疗,试验组采用泮托拉唑治疗。比较两组治疗前后血清PGE2水平及不良事件发生情况。结果:试验组消化道出血发生率为3.33%,显著低于参照组的30.00%,差异有统计学意义(P<0.05)。治疗前,两组PGE2水平比较,差异无统计学意义(P>0.05);治疗3、5、7 d后,试验组PGE2水平均明显高于参照组,差异均有统计学意义(P<0.05)。结论:在AMI后消化道出血患者中应用泮托拉唑,可降低消化道出血发生率,改善患者血清PGE2水平,具有较好的实践价值。

Objective:To analyze the effect of Pantoprazole on serum prostaglandin E2(PGE2)in patients with gastrointestinal hemorrhage after acute myocardial infarction(AMI).Method:A total of sixty patients with gastrointestinal hemorrhage after AMI admitted to our hospital from June 2018 to August 2019 were selected as study subjects.They were divided into control group and experimental group by random number table,30 cases in each group.On the basis of conventional symptomatic treatment,the control group was treated with Omeprazole,the experimental group was treated with Pantoprazole.Serum PGE2 levels before and after treatment and the occurrence of adverse events were compared between the two groups.Result:The rate of gastrointestinal hemorrhage in the experimental group was 3.33%,significantly lower than 30.00%in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in PGE2 level between the two groups(P>0.05);after 3,5 and 7 days of treatment,PGE2 levels in the experimental group were significantly higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Pantoprazole can reduce the incidence of gastrointestinal hemorrhage after AMI and improve the serum PGE2 level,which has good practical value.